海藻酸钠/钠化累托石接枝衣康酸凝胶膜的制备及性能研究

Study on preparation and properties of sodium alginate/Na^+ rectorite-graft-itaconic acid hydrogel films

通过水溶液聚合法制备海藻酸钠/钠化累托石接枝衣康酸凝胶膜(SA/Na+REC-g-IA),以吸水率及吸盐水率为目标考察了SA/Na+REC、KPS、NMBA用量及中和度等因素对产品的影响,获得最佳制备条件。利用FTIR、XRD、SEM及TEM对产品的结构及形态进行了表征。结果显示,凝胶膜展现插层结构及具有粗糙表面。和SA膜相比,SA/Na+REC-g-IA凝胶膜对水杨酸具有更优良的缓释功能,且释放机理符合费克定律。

Sodium alginate / Na^＋ rectorite-graft-itaconic acid（ SA / Na＋REC-g-IA） hydrogel film was prepared via solution polymerization. The effect of SA / Na^＋ REC,KPS and NMBA content and neultrallzation on absorption of water were investigated. The structure and morphology were analyzed by FTIR,XRD,SEM and TEM. Results revealed that the hydrogel film exhibited an intercalative structure and coarse surface. A slower and more continuous release of salicylic acid for SA / Na＋REC-g-IA composite hydrogel film was shown in vitro drug-controlled release studies,in comparison with SA film. The salicylic acid release mechanism of SA / Na＋REC-g-IA hydrogel film followed Fickian diffusion.