幽门螺杆菌感染与白塞氏病关系的荟萃分析

Relationship between Helicobacter pylori infection and Behcet′s disease:a meta-analysis

目的探讨幽门螺杆菌感染与白塞氏病之间的关系,明确幽门螺杆菌感染是否为白塞氏病的危险因素。方法使用计算机检索Pubmed数据库、Embase数据库、Cochrane图书馆系统等,纳入关于幽门螺杆菌感染与白塞氏病的病例对照研究,运用Revman5.2软件对文献实验数据进行荟萃分析,用固定效应模型或随机效应模型计算比值比（OR）及95%可信区间（95%CI）,同时进行敏感性分析、亚组分析和荟萃回归分析、评估异质性来源,Begg′s Test和Egger′s Test评价发表偏倚。结果 1999-2014年发表的七篇病例对照研究被最终纳入,包括1 155例患者,总幽门螺杆菌感染率为44.16%,白塞氏病组的幽门螺杆菌感染率高于对照组（56.72%和35.35%,OR=1.36,95%CI：1.01~1.84,P=0.04）。结论白塞氏病患者的幽门螺杆菌感染率高于健康人群。

OBJECTIVE To discuss the association between Helicobacter pylori（Hp）infection and Behcet′s disease,and to identify whether Hp is a risk factor for Behcet′s disease.METHODS A systematic literature search of PubMed,EMBASE and Cochrane library was conducted,which were included into the research of HP and Behcet′s disease.Revman 5.2was used for the Meta-analysis for empirical data from literature.A fixed or random effects model were used for calculating the odds ratio（OR）and a 95% credibility interval（95%CI）,at the same time sensitivity analysis,subgroup analysis and Meta-regression analysis were taken to evaluate the sources of heterogeneity.Begg′s Test and Egger′s Test were used to evaluate publication bias.RESULTS Seven case-control studies published between 1999 to 2014were finally identified,involving 1155 patients,with a total Hp infection rate of44.16%.The prevalence of Hp infection was greater in Behcet＇s disease patients than in controls（56.72% vs35.35%,OR=1.36,95%CI：1.01-1.84,P=0.04）.CONCLUSION The pooled data suggest a trend of more frequent Hp infections in patients with Behcet′s disease than healthy people.