利奈唑胺治疗老年髓系白血病患者革兰阳性球菌感染的效果分析

Effects of linezolid on treatment of gram-positive bacteria infections in elderly patients with myeloid leukemia

目的分析利奈唑胺治疗髓系白血病老年患者革兰阳性球菌感染的效果,从而为临床预防和诊治提供依据。方法随机选取2012年9月-2015年9月医院髓系白血病合并革兰阳性球菌感染患者20例为研究对象,按照治疗方法不同分为观察组及对照组,各10例,两组患者均给予头孢哌酮/舒巴坦治疗,观察组在此基础上联合应用利奈唑胺,分析利奈唑胺在老年髓系白血病合并革兰阳性球菌感染中的治疗效果。结果两组患者感染部位分布比较,差异无统计学意义;20例患者共检出病原菌30株,其中革兰阳性菌22株占73.33%,革兰阴性菌8株占26.67%,双重感染患者10例;观察组患者用药时间和体温恢复时间明显短于对照组,差异有统计学意义(P<0.05);观察组患者治疗有效率为90.00%,高于对照组80.00%,但差异无统计学意义;两组患者在治疗过程中均未出现药物相关心、肝功能异常者。结论利奈唑胺治疗老年髓系白血病合并革兰阳性球菌感染疗效显著,可以有效地缩短用药时间,体温恢复快,不良反应低,临床上值得推广。

OBJECTIVE To analyze the effects of linezolid on treatment of myeloid leukemia in elderly patients with gram-positive bacteria,so as to provide the basis for clinical prevention and treatment.METHODS A total of 20 patients with myeloid leukemia associated with gram-positive bacterial infections in the hospital from Sep.2010 to Sep.2015 were randomly selected for the study,and divided into observation group and control group according to the methods of treatment,with 10 cases in each group.Two groups of patients were treated with cefoperazone/sulbactam,and observation group were treated with linezolid on this basis.The effects of linezolid on treatment of myeloid leukemia in elderly patients with gram-positive bacteria were analyzed.RESULTS There was no significant difference in infection sites between the two groups.Totally 30 strains of pathogenic bacteria were detected from20 patients,including 22 strains of gram-positive bacteria,accounting for 73.33%,8strains of gram-negative bacteria,accounting for 26.67%,and 10 patients with dual infections.The average treatment time and body temperature recovery time of observation group were significantly shorter than those of control group,（P〈0.05）.The therapeutical effective rate of observation group was 90.00%,which was significantly higher than 80.00% of control group.There were no drug-related heart and liver function abnormalities of the two groups during treatment.CONCLUSIONLinezolid has good therapeutical effect on treatment of myeloid leukemia in elderly patients with gram-positive bacteria,it can effectively shorten the treatment time and body temperature recovery time,has low adverse events,so it is clinically worthy of promoting.