血清骨桥素、TNF-a水平与类风湿关节炎继发骨质疏松的相关性分析被引量：5

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摘要目的探讨类风湿关节炎(RA)合并骨质疏松血清骨桥素、TNF-a水平与病情相关性分析。方法选取RA95例,分为3组,RA合并OP患者35例,合并骨量减少30例,无OP患者30例,收集临床资料、实验室指标和疾病情况,对照组20例正常人,ELISA法检测血清骨桥素(SPP1),TNF-α水平,分析与疾病相关性分析。结果血清SPP1、TNF-a水平明显增高,与骨密度T值和发生骨折呈正相关。结论 RA合并OP中,SPP1、TNF-a作为骨代谢指标和炎症指标,可能参与了RA并发OP的发生,临床中指标升高提示了疾病的严重程度。

作者张斌刘丹杨浩杰王治伦曾玉红

机构地区西安交通大学医学院附属红会医院西安市第五医院西安交通大学地方病研究所

出处《中国地方病防治》 CAS 北大核心 2016年第7期816-816,820,共2页 Chinese Journal of Control of Endemic Diseases

基金陕西省自然科学项目(2015JM8422) 陕西省中医药管理局科研项目(2016-JC025) 西安市卫生科研项目(J201603041)

关键词 TNF-α 类风湿关节炎相关性分析骨质疏松骨桥素血清水疾病情况

分类号 R593.21 [医药卫生—内科学]

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