牛磺酸对慢性心脏衰竭影响及其机制的研究进展

Research progress on the effect and mechanism of taurine on chronic heart failure

牛磺酸作为体内各组织中分布广泛的内源性含硫氨基酸具有多种药理和生理作用,包括抗氧化活性、调节钙稳态及相关信号通路和抗细胞凋亡作用。越来越多的研究表明,牛磺酸在治疗心脏疾病方面具有良好的疗效,尤其是对慢性心脏衰竭(CHF)有特效。以往治疗慢性心脏衰竭的药物主要是通过抑制血管紧张素Ⅱ和阻断β-肾上腺素起作用,而机制主要是作用于交感神经系统和肾素—血管紧张素系统。文章针对牛磺酸通过神经体液因素抑制慢性心脏衰竭发生的机制进行综述。

As an endogenous sulfur - containing amino acid widely distributed in various tissues of the body, taurine has a variety of pharmaco- logical and physiological effects, including antioxidant activity, regulation of calcium homeostasis and related signaling pathways, and anti - apoptotic effects. More and more studies show that taurine has a good effect on the treatment of heart diseases especially chronic heart failure （CHF） with special effect. Previous drugs for CHF treatment are mainly depended on inhibiting vascular angiotensin Ⅱ and blocking beta - ad- renergic function, while the mechanism of which lies on the sympathetic nervous system and rennin - angiotensin angiotensin system. This paper reviews the mechanism of taurine inhibiting the occurrence of CHF through neurohormonal factors.