消疲饮干预脾肾两虚型慢性疲劳综合征的临床研究

Clinical Research on Xiaopi-Yin in the Treatment of Spleen-Kidney Deficiency Type Patients of Chronic Fatigue Syndrome

目的探讨消疲饮干预脾肾两虚型慢性疲劳综合征的临床有效性。方法将80例脾肾两虚型慢性疲劳综合征患者,分为治疗组42例和对照组38例。治疗组给予消疲饮口服,对照组给予维生素B6口服,连服6周为1个疗程。采用《SF-36生存质量》量表对干预前后受试对象的生存质量进行评定,采用《多维疲劳问卷(MFI-20)》评价干预前后受试对象的疲劳特征,以脾肾两虚相关症状总积分作为脾肾两虚证候的积分,评价干预前后中医症候变化情况;采用《团体用心理社会应激调查表》(PSSG)"对2组受试者干预前及干预期间的生活事件与应激反应临床症状积分、疲劳特征5个维度的积分明显低于治疗前(P<0.05),且治疗组积分明显低于对照组(P<0.05)。2组患者治疗后SF-36生存质量各项积分均较治疗前差异有统计学意义(P<0.05);治疗组治疗后在生理职能、身体状态、健康状况、精力、社会功能、精神健康积分,与对照组比较差异有统计学意义(P<0.05)。干预前和6周干预结束时,治疗组与对照组PSSG调查表5个因素比较,差异均无统计学意义(P>0.05)。结论消疲饮干预脾肾两虚型慢性疲劳综合征临床应用安全有效。

Objective To explore the clinical application of Xiaopi - Yin in the treatment of spleen - kidney deficiency type patients of chronic fatigue syndrome. Methods Eighty cases of spleen - kidney deficiency type patients of chronic fatigue syndrome were divided into two groups randomly, which including the treatment group（42 cases） and the control group（38 cases）. The treatment group was given Xiaopi - Yin by oral and the control group was given vitamin B6 by oral. The two kinds of intervention were lasted for 6 weeks, and then,the patients＇ quality of life was evaluated by SF - 36. Symptoms in TCM with symptom score of spleen - kidney deficiency type and fatigue characteristics with MFI -20 were conducted in pre and post treatment. Meanwhile,the life events and stress response were evaluated by PSSG in pre and post treatment. Result 6 weeks later,there were significantly different in the scores of symptom and fatigue characteristics between the two groups. （ P 〈 0. 05 ）. The scores in the treatment group were decreased significantly compared with the control group（ P 〈 0.05 ）. The scores of SF - 36 were significantly different between the two groups （ P 〈 0. 05 ）. After treatment, the scores of physical, function, physical state, health status, energy, social functions and mental health were significantly different between the pre and pro treatment in the treatment group（ P 〈 0. 05 ）. There was no statistical significance between the treatment group and the control group in five factors of PSSG in pre and post treatment. Conclusion The clinical application of Xiaopi - Yin in the treatment of spleen - kidney deficiency type patients of chronic fatigue syndrome is safe and effective.