摘要
目的对葛根素进行质量分析研究。方法以透明质酸为表面修饰剂、PEG-PLGA为载体材料,用纳米沉淀法制备透明质酸修饰的葛根素PEG-PLGA纳米粒(HA/Pue-NPs),采用高效液相色谱法(HPLC)对其进行载药量的测定,并考察透明质酸修饰的葛根素PEG-PLGA纳米粒的体外释药行为。结果制备出的载药纳米载药量为6.75%,体外释药试验表明,载药纳米粒释药缓慢,24 h的累计释放率为65.8%。结论透明质酸修饰的葛根素PEG-PLGA纳米粒质量性质良好,且体外具有一定的缓释特性。
Objective Taking PEG - PLGA as carrier to prepare Hyaluronic acid modified puerarin PEG - PLGA nanoparticles by Nano precipitation and measure its drug loading and conduct a pilot test on in vitro drug release behaviors. Method Taking Hyalurunic acid as surface modification agent and PEG - PLGA as carrier material to prepare HA/Pue - NPs by Nano precipitation. The drug loading capacity were measured through HPLC method and examined the drug release behaviors in vitro by PEG - PLGA. Result The drug loading capacity of prepared drug - loading nanoparticles was 6.75%. The test of drug release in vitro showed that the drug - loading nanopartieles released slowly,the accumulative release rate in 24h was 65.8%. Conclusion The hyaluronic acid modified puerarin PEG - PLGA nanoparticles has good in vitro properties and slow - release characteristics.
出处
《宁夏医学杂志》
CAS
2016年第10期928-929,共2页
Ningxia Medical Journal
