摘要
Rab1可调节血管内皮细胞等组织细胞,血管紧张素Ⅱ1型受体(AT1R)从内质网经高尔基体到细胞表面的顺向运输。血管紧张素Ⅱ不但能增加内皮祖细胞(EPCs)的数量,而且能改善EPC的增生、迁移、黏附和体外血管生成能力,AngⅡ通过AT1R介导上调内皮祖细胞的血管内皮生长因子等多种促血管新生的细胞因子的表达,促进血管再生。Rab1蛋白介导AT1R囊泡运输在复元醒脑汤治疗糖尿病脑梗死的作用机制中可能是其关键点。
Rabl can adjust histocytes, such as vascular endothelial cells, AT1R follow endoplasmic reticulum via golgi arriving to the consequent on the surface of the cell. Angiotensin Ⅱ can not only increase the number of endothelial progenitor cells, but also improve the proliferation, migration, adhesion of EPC and in vitro angiogenesis ability and can also upregulate the expression of variety of angiogenic cytokines including vascular endothelial growth factor of progenitor cells and so on by AT 1R mediation so as to promote angiogenesis. Rabl protein-mediated AT1R＇s vesicle transport is an important mechanism for Fuyuan Xingnao decoction for the treatment of diabetic cerebral infarction.
作者
刘月
方邦江
王晓翠
孙丽华
LIU Yue FANG Bangjiang WANG Xiaocui SUN Lihua(Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, Chin)
出处
《上海医药》
CAS
2016年第19期45-47,63,共4页
Shanghai Medical & Pharmaceutical Journal
基金
国家自然科学基金项目支持(项目编号:81573923)
国家自然科学基金项目支持(项目编号:81273725)
关键词
Rab1蛋白
囊泡运输
血管重构
复元醒脑汤
Rab 1 protein
vesicular transfer
vascular remodeling
Fuyuan Xingnao decoction
