不同剂量5% 5-盐酸氨酮戊酸光动力治疗面部中重度痤疮疗效观察

The Clinical Effect of Different Doses of 5% 5-Aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Facial Acne

目的观察不同剂量5%5-盐酸氨酮戊酸溶液光动力疗法（ALA-PDT）治疗面部中重度痤疮的安全性与疗效。方法 88例面部中重度痤疮患者随机2组,A组47例外用4.5 m L 5%5-ALA,B组41例外用2.2 m L 5%5-ALA,7~10 d重复治疗1次,连续治疗3次。每次治疗后及末次治疗后第1、4、8、12、24周进行疗效评价并记录不良反应。结果 81例患者完成全部治疗（A组45例,B组36例）,治疗3次后A组有效率（100%）高于B组（8.89%）,差异有统计学意义（P〈0.05）;A组痊愈率（97.78%）高于B组（80.56%）,差异有统计学意义（P〈0.05）。A组再次复发率为（9.09%）低于B组（38.46%）,差异有统计学意义（P〈0.01）。不良反应A、B两组分别为33.33%、30.55%,差异无统计学意义（P〉0.05）。结论固定敷药时间时,外用4.5 m L 5%5-ALA-PDT疗效好,复发率低,不良反应未见明显增加。

Objective To observe the safety and efficacy of different doses of 5% 5- aminolevulinic acid photodynamic therapy（ ALA-PDT） for moderate and severe facial acne.Methods 88 cases with moderate and severe facial acne were divided into Group A（ 47 cases） and Group B（ 41 cases）.The Group A received 4.5ml of 5% 5- ALA and Group B received 2.2ml of 5% 5-ALA.They were repeated the treatment 1 times 7 ~ 10 days,3 times in a row.The efficacy and adverse reactions were evaluated after each time and 1,4,8,12 and 24 weeks after the last time.Results 81 patients completed the treatment（ Group A of 45 cases,Group B of 36 cases）.After 3 times of treatment,the effective rate of Group A（ 100%） was higher than that of Group B（ 88.89%） and the difference was statistically significant（ P〈0.05）.The recovery rate of Group A（ 97.78%） was higher than that of Group B（ 80.56%） and the difference was statistically significant（ P〈0.05）.The recurrence rate of Group A（ 9.09%） was lower than that of Group B（ 38.46%） and the difference was statistically significant（ P〈0.01）.The adverse reactions of Group A and Group B were respectively 33.33% and 30.55%.There was no statistical difference（ P〉0.05）.Conclusion 4.5 m L 5% 5- ALA- PDT has good curative effect,low recurrence rate and no significant increase in adverse reactions.