成都地区乙型肝炎病毒感染者病毒基因型和亚型分布及其临床意义

Distribution and Clinical Significance of HBV Genotypes and Subtypes in Chengdu Area

目的探讨成都地区乙型肝炎病毒(HBV)感染者病毒基因型和亚型分布及其临床意义。方法采用PCR检测法对成都地区随机选取的216例HBV感染患者的病毒基因型以及亚型的分布情况进行研究,分析成都地区乙型肝炎病毒感染者病毒基因型和亚型分布情况及不同类型HBV感染者基因型频率有无差异。结果 216例HBV感染患者的血清检测结果显示,70例为B基因型(32.4%),105例为C基因型(48.6%),B+C混合感染型41例(19.0%),混合型显著低于B型和C型(P<0.05)。无症状携带者以B型感染为主,慢性乙型肝炎以B型和C型为主,肝硬化及肝癌以C型为主,不同类型HBV感染者基因型分布频率存在统计学差异(P<0.05)。结论成都地区乙型肝炎病毒感染以B型和C型为主,C型感染可能是本地区HBV感染者肝硬化及肝癌的高危因素。

Objective To explore the distribution and clinical significance of HBV genotypes and subtypes in Chengdu area.Methods 216 cases with HBV were collected from Chendu and the genotype and subtypes of HBV patients were tested by PCR method. The distribution of HBV genotypes and subtypes and the difference of genotype frequencies for different types of HBV were analyzed.Results The serum detection results of 216 HBV cases showed that 70 cases were genotype B（ 32.4%）,105 cases were genotype C（ 48.6%） and 41 cases were B ＋C mixed type（ 19. 0%）. The mixed type was significantly lower than genotype B and C（ P〈0. 05）. The asymptomatic carriers were mainly genotype B,chronic hepatitis patients were genotype B and C and liver cirrhosis and liver cancer patients were genotype C. There was a statistical difference among genotype frequencies for different types of HBV（ P〈0. 05）. Conclusion The HBV infection in Chengdu was mainly based on genotype B and C.The genotype C may be a high risk factor for liver cirrhosis and liver cancer for HBV patients in the area.