细辛脑注射液治疗慢性阻塞性肺疾病急性加重期疗效的Meta分析

Meta Analysis of Curative Effect of Asarone Injection on the Treatment of Chronic Obstructive Pulmonary Disease with Acute Exacerbation

目的评价细辛脑注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法计算机检索Pub Med、中国期刊全文数据库(CNKI)、万方数据库(Wanfang)和维普数据库(VIP),查找关于细辛脑注射液治疗AECOPD的随机对照试验(RCT),提取资料,采用Reviewmanager 5.2软件进行分析。结果共纳入12个研究,共873例病例,797例对照,Meta分析显示:细辛脑注射液+常规治疗组的总有效率优于常规治疗组[OR=4.41,95%Cl(3.17,6.13),(P<0.0001)];细辛脑注射液+常规治疗组对患者的血气分析均有较好的改善作用,氧分压(Pa O2)[MD=8.50,95%CI(7.28,9.72),P<0.00001],二氧化碳分压Pa CO2[MD=-4.55,95%CI(-6.67,-2.43),P<0.0001]。结论现有证据表明,细辛脑注射液治疗AECOPD有一定效果,可提高治疗总有效率、改善患者的动脉血气指标,由于本次纳入研究质量偏低,结论需谨慎应用,今后尚需进一步开展设计严谨、多中心大样本的临床研究增加其论证强度。

Objective ： To evaluate the curative effect of Asarone Injection on the treatment of chronic obstructive pulmonary disease with acute exacerbation （AECOPD）. Methods： PubMed, CNKI, Wanfang Database and VIP data- base have been searched for the randomized controlled trials （RCT） of Asarone Injection therapy of AECOPD by com- puter, and Reviewmanager 52 software was used for its analysis. Results： 12 studies were included, a total o1873 cases and 797 control cases. Meta analysis showed： The total effectiveness of Asarone Injection ＋ conventional treatment groups was better that of conventional treatment groups [ OR = 441,95 % C1 （ 317,613 ）, （ P 〈 00001 ） ]. The blood gas analysis of Asarone Injection ＋ routine treatment groups showed improvement, oxygen partial pressure （ PaO2 ） [ MD = 850,95 % C I （728,972） , P 〈 000001 ] , carbon dioxide partial pressure PaCO2 [ MD = - 455,95% CI （ - 667, - 243 ）, P 〈 00001 ]. Conclusion ： The available evidence suggests Asarone Injection treatment has certain effect for AE- COPD, and can improve the overall effect of the treatment and raise the arterial blood gas of the patients. As this study includes low quality, the conclusion would be applied cautiously. The future study needs to be conducted with rigorous design, multi -center large sample clinical study to increase its argument strength.