紫草汤治疗湿热瘀阻型多囊卵巢综合征的临床疗效

Clinical Effect of Lithospermum Decoction on the Treatment of Polycystic Ovary Syndrome Patients with Dampness and Hotness Obstruction

目的分析观察紫草汤联合西药治疗湿热瘀阻型多囊卵巢综合征的临床疗效。方法选取于本院诊治的湿热瘀阻型多囊卵巢综合征的患者60例,采用随机数字表法分为观察组和对照组,对照组30例患者给予常规西药治疗,观察组30例患者给予常规西药联合紫草汤治疗。分析比较2组患者的临床疗效、不良反应发生率和治疗前后的卵泡雌激素(FSH)、黄体生成素(LH)水平、睾酮(T)、黄体生成素与卵泡雌激素的比值(LH/FSH)变化。结果治疗前,2组患者的FSH、T、LH、LH/FSH比较无统计学意义(P>0.05);治疗后,2组患者的FSH较治疗前无明显变化,比较无统计学意义(P>0.05);T、LH、LH/FSH显著降低,观察组患者的T、LH、LH/FSH水平低于对照组,差异有统计学意义(P<0.05);观察组患者的临床疗效优于对照组患者,差异有统计学意义(P<0.05);观察组患者的不良反应发生率低于对照组患者,差异有统计学意义(P<0.05)。结论紫草汤联合西药治疗湿热瘀阻型多囊卵巢综合征疗效显著,安全性高,值得临床推广使用。

Objective： To analyze of clinical effect of Lithospermum Decoction combined with western medicine on the treatment of polycystic ovary syndrome patients with dampness and hotness obstruction. Methods： 60 patients were selected and randomly divided into an observation group and a control group, 30 cases per group. The control group was treated with conventional western medicine while the observation group was treated with conventional medicine combined with Lithospermum Decoction. The clinical effect and the incidence of adverse reactions of the two groups and their FSH, luteinizing hormone （LH）, testosterone （T）, and the changes of luteinizing hormone and follicle estrogen （LH/FSH） ratio were compared before and after the treatment. Results： Before the treatment, the comparison of FSH, T, LH, LH / FSH of the two groups showed no statistical significance （P 〉 005）. After the treatment, the comparison of FSH of the two groups had no significant change compared with the pre -treatment, no statistically significant （P 〉 005）, but their T, LH, LI-I/FSH significantly decreased. The level of T, LH, LH/FSH of the observation group was lower than that of the control group, and the difference was statistically significant （P 〈 005 ）. The clinical effect of the observation group was better than that of the control group and the differ- ence was statistically significant （P 〈 0.05）. The incidence of adverse reactions of the observation group was lower than that of the control group and the difference was statistically significant （P 〈 0.05）. Conclusion ： Lithospermum Decoction combined with western medicine has obvious effect on the treatment of polycystic ovary syndrome with dampness and hotness obstruction, safe and worthy of more clinical appli- cation.