广宁地区非酒精性脂肪肝相关危险因素的Logistic回归分析

Logistic Regression Analysis on Relative Risk Factors of Nonalcoholic Fatty Liver Disease in Guangning areas

目的:探讨广宁地区非酒精性脂肪肝(NAFLD)的患病情况及相关危险因素,为NAFLD的防治提供科学依据。方法:随机选取2014年1月-2015年8月于本院门诊体检经B超确诊的NAFLD患者228例作为病例组,另择同期体检健康人员228例作为对照组,比较两组肥胖、血压、肝功能、血脂及空腹血糖(FPG)水平,并对其相关危险因素进行多因素Logistic回归分析。结果:NAFLD检出率为19.0%;病例组体重指数(BMI)、腰臀围比(WHR)、收缩压(SBP)、舒张压(DBP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均高于对照组,高密度脂蛋白(HDL-C)低于对照组,比较差异均有统计学意义(P<0.05);多因素Logistic回归分析显示,BMI、WHR、SBP、DBP、TC、TG、LDL-C是NAFLD的独立危险因素,HDL-C是其保护因素。结论:肥胖、高血压和血脂紊乱是本地区人群NAFLD三大独立危险因素,应开展定期临床检查,改变人们不良生活习惯,是降低非酒精性脂肪肝发病率的重要途径。

Objective： To explore the prevalence of nonalcoholic fatty liver disease （ NAFLD ） and its relative risk factors in Guangning areas, aim to provide scientific basis for the prev＇ention and control NAFLD. Method： From January 2014 to August 2015, 228 cases of NAFLD in our hospital outpatient examination by B ultrasound diagnosis were selected as the case group, 228 cases of physical health person were selected as the control group, two groups of obesity, blood pressure, liver function, blood lipids and fasting blood glucose （ FPG ） levels were compared, and the related risk factors were analyzed by multi factor Logistic regression analysis. Result： The detection rate of NAFLD was 19.0%, the body mass index cases （ BMI ）, waist hip ratio （ WHR ）, systolic blood pressure （ SB.P ）, diastolic blood pressure （ DBP ）, a]anine aminotransferase （ ALT ）, aspartate aminotransferase （ AST ）, total cholesterol （ TC ）, triglyceride （ TG ） and low density lipoprotein （ LDL-C ） in case group were higher than those of the control group, high density lipoprotein （ HDL-C ） was lower than the control group, the differences were statistically significant （P〈0.05） .Multi factor Logistic regression analysis showed that BMI, WHR, SBP, DBP, TC, TG, LDL-C were the independent risk factors of NAFLD and HDL-C was the protective factor.Conclusion： The obesity, hypertension and dyslipidemias are three major independent risk factor for NAFLD population in Guangning areas.Taking periodic clinical examination and changing bad habits are the important ways to reduce the incidence of NAFLD.