EB病毒与炎症性肠病

Epstein-Barr virus and inflammatory bowel disease

EB病毒（EBV）是首个发现的与肿瘤发生相关的人类病毒，EBV感染和炎症性肠病有一定的相关性，但原因不明。研究发现IBD患者中肠黏膜感染EBV的比例大大增加，并且EBV感染和IBD病情加重及其难治性病程相关。免疫抑制治疗明显改善了IBD的预后，但可能造成机会感染增加，并诱发可能与EBV相关的淋巴组织增殖性疾病。本文总结了目前对EBV造成肠黏膜炎症的病理生理机制、EBV与IBD病情加重及淋巴组织增殖性疾病的关系的认识及相应的临床对策。

Epstein-Barr Virus （EBV） is the first human virus related to oncogenesis. EBV infection is associated with inflammatory bowel disease （IBD） with unknown causality. The prevalence of EBV in intestinal tissue from patients with IBD is significantly higher and related to the exacerbation of the disease and refractory IBD. Immunosuppressive therapy has improved Outcomes associated with IBD. However, it is also associated with an increased risk of opportunistic infection, and lymphoproliferative disorders （LDs） maybe due to EBV infection. Here we review our current understanding of the pathogenesis of EBV infection in colonic mucosal inflammation, EBV-induced disease exacerbation, lymphomagenesis in IBD, and clinical approaches therefrom.