炎症性肠病与真菌关系的研究进展

Research progress of the relationship between inflammatory bowel disease and fungus

炎症性肠病（IBD）是一种病因不明的慢性肠道炎症性疾病，包括溃疡性结肠炎和克罗恩病。目前，随着全球炎症性肠病发病率的逐年增高，肠道微生态在疾病演变中的作用引起了越来越多的关注，而肠道真菌作为肠道微生物系统的重要组成部分，其在疾病状态中的变化及所起的作用尚不明确。本文将从肠道真菌的组成和分布、其与肠道细菌、免疫反应的关系等方面，就肠道真菌在炎症性肠病的发生发展中发挥的作用进行综述。

Inflammatory bowel disease （IBD） is a chronic intestinal inflammatory disease with un-known etiology, including ulcerative colitis （UC） and Crohn＇s disease （CD）. At present, as the global incidence of inflammatory bowel disease is increasing year by year, the role of the intestinal micro ecology in disease evolution has attracted more and more attention, and as an important part of gut microbes system, the intestinal fungus＇changes and effects in disease states are unclear. This paper reviews on the intestinal fungus in the occurrence, development of inflammatory bowel disease from the composition and distribution of the intestinal fungus and its relationship with the gut bacteria, and the immune reaction.