莉芙敏干预围绝经期综合征临床观察

Clinical Observation on Remifemin in the Intervention of Perimenopausal Syndrome Women

目的观察莉芙敏对围绝经期综合征妇女血清5-HT水平的影响及治疗前后各证素积分的变化。方法选择符合纳入标准的围绝经期综合征妇女23例,进行莉芙敏干预治疗12周,分析比较治疗前后主要的证素积分、FSH、LH、E2、5-HT的变化。结果莉芙敏干预前后5-HT水平存在差异,但差异无统计学意义(P>0.05);干预前后FSH、LH、E2差异均无统计学意义(P>0.05);干预前后肾、肝、脾、心神、阴虚、气虚、血虚、气滞、阳亢、湿、热积分差异有统计学意义(P<0.05);干预前后阳虚、血瘀积分差异无统计学意义(P>0.05)。结论莉芙敏适用于证素在肝、心神、阴虚、湿、热、阳亢等患者。

Objective To observe serum level of 5-HT and syndrome elements score before and after Remifemin in the treatment of perimenopausal syndrome women. Methods 23 cases of perimenopausal women met the inclusion criteria of the syndrome were selected. Remifemin intervention trials were conducted for 12 weeks. Before and after treatment, the primary syndrome elements score, level of FSH, LH, E2 and 5-HT were analyzed and compared. Results The difference was not statistically significant in the levels of 5-HT before and after Remifemin intervention （P 〉 0. 05 ）. The FSH, LH and E2 were no significant difference before and after intervention （ P 〉 0. 05 ）. The kidney, liver, spleen, mind, yin deficiency, qi deficiency, blood deficiency, qi stagnation, hyperactivity of yang, wet and hot points difference were statistically significant before and after intervention （ P 〈 0.05）. The yang deficiency and blood stasis points＇ difference was not statistically significant before and after intervention （P 〉 0.05 ）. Conclusion Remifemin is suitable for syndrome elements in the liver, mind, yin deficiency, wet, hot and hyperactivity of yang patients.