基于数据挖掘探讨韦贵康治疗颈椎病的用药特点

Exploration on medication rule of WEI Gui-kang's Chinese medicine master in Gui school in the treatment of cervical spondylosis based on data mining

目的:整理与总结韦贵康教授的治疗颈椎病用药规律,以期为中医中药治疗颈椎病提供有益参考。方法:收集韦教授首诊运用中药治疗颈椎病病例,对符合纳入标准的病例中使用的中药进行统计,运用SPSS 19 for Windows统计软件对中药的频数、聚类规则进行分析,运用clementine 12.01统计软件对韦老治疗颈椎病的用药规律进行数据挖掘。结果:1共有162份病例符合纳入标准,其中131味中药符合统计要求,总计出现频次1 646次,高频率中药有甘草、白芍、丹参、川芎等32味中药。2补益药、活血化瘀、解表药为韦教授治疗颈椎病的常用中药。3常用的药对有:丹参与田七;降香与两面针;田七与两面针;龙骨与降香;杜仲与续断;甘草与龙骨;丹参与龙骨;黄芪与升麻等。4常用的基本方药有:痛安汤、六君子汤、姜黄汤、防风白芷茶等。5常用引经药为肝经(川芎、当归);脾经(黄芪、升麻);肾经:(续断、杜仲)。结论:韦贵康教授治疗颈椎病体现补肾通督、化瘀扶正的学术思想,安痛汤是其自创常用基础方,数据挖掘结果客观反映了韦贵康教授临床用药的规律及特点。

Objective： To analyze the medication rule of cervical spondylosis treated by WEI Gui-kang, a national famous TCM expert, in order to provide reference for the treatment of cervical spondylosis by Chinese medicine. Methods： One hundred and sixty-two cases of cervical spondylosis were collected, in which patients were treated with TCM by professor WEI. SPSS 19 for Windows were used to analyze the frequency and the clustering rules of TCM, and the clementine 12.01 statistics software were used for data mining of the medication rule of Prof. WEI Gui-kang in the treatment of cervical spondylosis. Results： 1A total of 162 cases were included into the inclusive criteria, where 131 traditional Chinese medicines were in accordance with the requirements of the statistics, and their frequency was 1 646 times. A total of 32 traditional Chinese medicines with high frequency were Radix Glycyrrhizae, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Rhizoma Ligustici Chuanxiong, etc. 2The drugs including invigoration drugs, drugs used to activate blood flow and drugs of relieving exterior syndrome were commonly presecribed by professor. WEI in the treatment of cervical spondylosis. 3The couplet medicines commonly used by professor. WEI included Radix Salviae Miltiorrhizae and Radix Notoginseng, Lignum Dalbergiae Odoriferae and Radix Zanthoxyli, Radix Notoginseng and Radix Zanthoxyli, Os Draconis and Lignum Dalbergiae Odoriferae, Cortex Eucommiae and Radix Dipsaci, Radix Glycyrrhizae and Os Draconis, Radix Salviae Miltiorrhizae and Os Draconis, Radix Astragali seu Hedysari and Rhizoma Cimicifugae,etc. 4The basic formulas commonly used by professor WEI included Tongan Decoction, Liujunzi Decoction, Jianghuang Decoction, Fangfeng Baizhi Tea, etc. 5The messenger drugs commonly used by professor WEI included Rhizoma Ligustici Chuanxiong and Radix Angelicae Sinensis for the liver channel, Radix Astragali seu Hedysari and Rhizoma Cimicifugae for the spleen channel, and Radix Dipsaci and Cortex Eucommiae for the kidney channel. Conclusion： The academic ideology of ‘Tonifying kidney and dredging governor meridian, removing blood stasis and strengthening the body resistance＇ is reflected inprofessor WEI Gui-kang＇s treatment of cervical spondylosis. The Tong＇an Decoction is his basis decocion for treatment of cervical spondylosis. Data mining results objectively reflect the law and characteristics of professor WEI Gui-kang＇s clinical medication.