原发性甲状腺功能亢进症患者血尿酸相关性研究

Study on the Correlation of Serum Uric Acid in Patients with Primary Hyperthyroidism

[目的]探讨原发性甲状腺功能亢进症（甲亢）患者血尿酸（UA）与甲状腺功能水平的相关性。[方法]收集原发性甲亢患者61例，按照血UA水平（男性〉420umol／L，女性〉360umol／L）分为高尿酸血症（HUA）组、正常尿酸血症（NUA）组，另外收集同期年龄和性别匹配的健康体检人群作为健康对照组，检测并比较三组甲状腺功能指标[游离三碘甲腺原氨酸（FTS）、游离甲状腺素（FT4）、促甲状腺激素（TSH）水平]、空腹血糖（FBS）、肾功能指标[尿素氮（BUN）、肌酐（Cr）、UA]；肝功能[丙氨酸基转移酶（ALT）和天冬氨酸氨基转移酶（AST）]、血脂[三酰甘油（TG）、胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）]，分析UA与甲状腺功能水平的相关性。[结果]NUA组FT3、FT4均明显高于对照组（P〈0．01），而TC、HDL-C、LDL-C、TSH均明显低于对照组（P〈0．01），但两组FBS、AST、TG、BUN、Cr、UA比较差异无统计学意义（P〉0．05）。与NUA组比较，HUA组BUN、UA、Cr、FT3、FT4明显升高（P〈0．05），TSH水平明显下降，其差异均有统计学意义（P〈0．05）；而两组FBS、AI，T、AST、TG、TC、HDL-C、LDL-C比较差异无统计学意义（P〉0．05）。UA与FT3、FT4呈正相关（P〈0．05），与TSH呈负相关（P〈0．05），血清Cr与FT3、FT4呈负相关（P〈0．05）。[结论]原发性甲亢患者易合并血UA升高，血UA水平与患者的高甲状腺激素水平密切相关。

[Objective]To investigate the correlation between serum uric acid （UA） and thyroid function in pa tients with primary hyperthyroidism.[Methods]Sixty-one cases of primary hyperthyroidism were collected, and were divided into hyperurieemia （HUA） group and normal uric acid （NUA） group according to the blood UA level （male 〉420 mol / L, female 〉 360μmol/L）. In addition, healthy physical examination population of the same age and gender matched were collected as a healthy control group. The following were detected and compared in the three groups including the thyroid function indicators： free three iodine thyroid gland （FT3）, free thyroid hormone （FT4）, thyroid stimulating hormone （TSH） level）, Fasting blood glucose （FBS） ; the renal function： blood urea nitrogen （BUN）, creatinine （Cr）, UA; the liver function： alanine aminotransferase （ALT） and aspartate aminotransferase （AST） ;the blood lipids： three glycerol （ TG）, cholesterol （TC）, high density lipoprotein （HDL-C）, low density lipoprotein （LDL-C） . The correlation between UA and thyroid function was analyzed.[Resuhs]FT3 and FT4 in the NUA group were significantly higher than the control group （ P 〈0.01）, while the TC, HDL-C, LDL-C, TSH were significantly lower than the control group （ P 〈0.01）, but there was no significant difference between the two groups in FBS, AST, TG, BUN, Cr , UA （ P 〉0.05）. Compared with NUA group, BUN, UA, Cr, FT3, FT4 of the HUA group were significantly increased （ P 〈0.05）, TSH level was significantly decreased, and the difference was statistically significant （ P 〈0.05）; there was no significant difference in FBS, ALT, AST, TG, TC, HDL-C, LDL-C in the two groups （ P 〉0.05）. UA was positively correlated with FT3 and FT4 （ P 〈0.05）, and was negatively correlated with TSH （ P 〈0.05）, Serum Cr was negatively correlated with FT3 and FT4 （ P 〈0.05）. [Conclusion]Patients with primary hyperthyroidism can be easily combined with blood UA elevation. The level of serum UA is closely related to the level of thyroid hormone of patients.