腹腔镜胃癌根治术治疗进展期胃癌对患者血清应激炎症因子的影响

Effects of Laparoscopic Radical Surgery for Advanced Gastric Cancer on Patient＇s Serum HO-1, TNF-α, IL-6, and CRP

[目的]探讨腹腔镜胃癌根治术治疗进展期胃癌对患者血清血红素加氧酶-1（HO- 1）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C反应蛋白（CRP）水平的影响。[方法]在本院行根治性手术治疗的进展期胃癌患者80例，按照手术方式不同分为腹腔镜组和开腹组，比较两组患者手术情况及手术前后血清HO-1、TNF-α、IL-6、CRP含量的差异。[结果]腹腔镜组的手术时间长于开腹组，术中出血量、切口长度、肛门排气时间、住院时间低于开腹组，且差异具有显著性（P〈0．05）；两组术后并发症发生率相比较差异无显著性（P〉0．05）。手术后腹腔镜组血清HO-1、TNF-α、IL-6、CRP均低于开腹组，且差异具有显著性（P〈0．05）。[结论]腹腔镜胃癌根治手术较开腹根治手术治疗进展期胃癌其出血量少，切口小、患者恢复快、引起机体的应激反应轻。

[Objective]To examine the effect of laparoscopic radical gastrectomy for advanced gastric cancer on Patienfs serum HO-1, TNF-α, IL-6, and CRP. [Methods]A total of 80 patients with advanced gastric cancer who underwent surgery in our hospital were selected. They were divided according to operation method into a laparoscopic radical gastrectomy group and an open radical gastrectomy group. The difference in operation condition between the two groups was compared.The differences of serum levels of HO-1, TNF-α, IL-6 and CRP before and after operation were compared between the two groups. [Results]The operation time in the laparoscopic group was longer than that in the open surgery group. The amount of blood loss, incision length, anal exhaust time, and hospitalization time were shorter in the laparoscopic group than the open surgery group, and the difference was statistically significant （ P 〈0.05）. There was no significant difference in the incidence of postoperative complications between the two groups （ P 〉0.05）. The levels of serum HO-1, TNF-α, IL-6 and CRP in the laparoscopic group were lower than those in the open group, and the difference was statistically significant （ P 〈0.05）. [Conclusion] Laparoscopic radical gastrectomy for advanced gastric cancer causes less bleeding, smaller incision, less stress response as well as a faster recovery.