基于体素的形态学分析偏头痛患者灰质异常:Meta分析

Analysis of gray matter abnormalities based on voxel-based morphometry in migraine patients:Meta-analysis

目的采用激活似然估计(ALE)的Meta分析方法,探讨偏头痛患者基于体素的形态学(VBM)分析所得的脑灰质改变。方法在中国知网、PubMed和Embase数据库中检索从2000年1月—2015年6月间基于VBM的偏头痛患者灰质变化的文献,然后通过GingerALE软件包对所检索结果进行Meta分析。结果检索后共纳入包括246例偏头痛患者和245名健康对照者的10项研究。偏头痛患者双侧额下回(BA44区)、右侧中央前回(BA43、44区)、双侧额中回(BA6、9区)、双侧扣带回前部(BA32区)、左侧扣带回(BA24区)、右侧颞上回(BA22区)、左侧岛叶(BA13区)、右侧顶下小叶(BA40区)灰质与健康对照者比较均显著减少(P均<0.05)。结论偏头痛患者脑灰质结构的改变为进一步研究与疼痛有关的脑神经网络的病理、生理机制提供了形态学依据。

Objective To investigate the changes of brain gray matter in migraine patients obtained by voxel-based morphometry （VBM） with meta-analysis of activation likelihood estimate （ALE）.Methods A systematic search in CNKI, PubMed and Embase database from January, 2000 to June, 2015 was performed to identify VBM studies that analyzed changes of brain gray matter of migraine patients. A quantitative meta-analysis was performed using the ALE method.Results Ten studies consisting of 246 migraine patients and 245 healthy controls were included. Regional gray matter atrophy in migraine patients was found in the bilateral inferior frontal gyrus （BA44）, right precentral gyrus （BA43, BA44）, bilateral medial frontal gyrus （BA6, BA9）, bilateral anterior cingulate （BA32）, left cingulate gyrus （BA24）, right superior temporal gyrus （BA22）, right insula （BA13）, right inferior parietal lobule （BA40）.Conclusion A characteristic pattern of gray matter abnormalities in migraine patients can provide some morphological basis to further researchwork in pathology and physiology of neural network related pain.