糖化白蛋白的临床意义

Clinical Significance of Glycated Albumin

动脉粥样硬化是脑梗死、冠状动脉性心脏病及外周血管疾病的主要病因，严重危害人类健康。糖化白蛋白是血液中葡萄糖与白蛋白N端发生非酶促糖化反应形成的，可有效反映糖尿病患者2～3周平均血糖水平。糖化白蛋白与动脉粥样硬化、糖尿病、脑梗死疾病密切相关。糖化白蛋白可通过促进炎症反应、血小板聚集、血栓形成以及影响胆固醇逆向转运，导致糖尿病患者动脉粥样硬化的进展。从而促进心脑血管疾病的发生。因此糖化白蛋白不仅是血耱控制指标，还可能成为动脉粥样硬化患者重要的新的临床检测指标。

Atherosclerosis （ As ） is a major cause of cerebral infarction, coronary heart disease and peripheral vascular disease, which is very harmful to the human health. Glycated albumin is a substance gen- erated by blood glucose and N-terminal of albumin through non-enzymatic reaction, which can effectively reflect average blood glucose level of diabetics for two-three weeks. Glycated albumin is closely related to As, diabetes and stroke. Glycated albumin contributes to the progression of As in the diabetics through promoting inflammatory reaction, platelet aggregation, thrombosis and influencing cholesterol reverse transport, thus leading to the occurrence of cardiovascular disease, therefore, glyeated albumin is not only a blood glucose control target but may also become a new clinical testing indicator for As.