摘要
目的探讨诱导型一氧化氮合酶(i NOS)在鳞状细胞癌(SCC)中的表达及其临床意义。方法采用免疫组织化学技术检测30例鳞状细胞癌(Ⅰ级13例,Ⅱ~Ⅲ级17例)、25例光线性角化病(AK)、10例正常皮肤组织中i NOS的表达。结果鳞状细胞癌组与光线性角化病组间对比,差异无统计学意义(P〉0.05)。Ⅱ+Ⅲ级鳞状细胞癌i NOS表达高于Ⅰ级鳞状细胞癌(P〈0.05)。结论皮肤SCC及AK中存在i NOS的表达可能有助于SCC的恶性度及预后的判断,从而指导临床治疗。
Objective To investigate the expression of inducible nitric oxide synthase(i NOS) in squamous cell carcinoma(SCC) and its clinical significance. Methods Using immunohistochemistry to detect 30 cases of squamous cell carcinoma(13 cases of grade I, II and III in 17 cases), 25 cases of actinic keratosis(AK) and the expression of i NOS in 10 cases of normal skin tissues. Results Squamous cell carcinoma and actinic keratosis group comparison between groups, the difference was not statistically significant(P〉0.05). The expression of i NOS in the second and third stage squamous cell carcinoma was higher than that of the first stage squamous cell carcinoma(P〈0.05). ConclusionThe expression of i NOS in skin SCC and AK may be helpful to judge the degree of malignancy and prognosis of SCC, so as to guide clinical treatment.
出处
《中国继续医学教育》
2016年第27期26-27,共2页
China Continuing Medical Education
关键词
一氧化氮
鳞状细胞癌
免疫组织化学
Nitric oxide
Squamous cell carcinoma
Immunohistochemistry