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利拉鲁肽治疗2型糖尿病伴肥胖症患者的临床效果观察 被引量:7

To Observe the Clinical Effect of Liraglutide Treatment in Type 2 Diabetic Patients With Obesity
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摘要 目的观察利拉鲁肽治疗2型糖尿病伴肥胖症患者的临床效果。方法以2013年2月~2016年1月来我院治疗的60例2型糖尿病伴肥胖症患者作为研究对象,随机分成对照组(盐酸二甲双胍联合甘精胰岛素治疗)与观察组(盐酸二甲双胍联合利拉鲁肽治疗),各30例。对比2组患者治疗后BMI、FPG以及2 h PG的变化情况。结果观察组患者治疗后的BMI、FPG以及2 h PG的改善情况均优于对照组患者(P〈0.05)。结论利拉鲁肽治疗2型糖尿病伴肥胖症患者的临床效果显著。 Objective To observe the clinical effect of liraglutide treatment with obesity in patients with type 2 diabetes mellitus. Methods In type 2 diabetes from February 2013 to January 2016 in our hospital for treatment of 60 cases of patients with obesity as the research object, randomly divided into control group(metformin combined with insulin glargine treatment) and observation group(metformin and liraglutide treatment), 30 cases in each. The changes of BMI, FPG and 2 h PG were compared between the 2 groups after treatment. Results The improvement of BMI, FPG and 2 h PG after treatment in the observation group were better than those in the control group(P〈0.05). Conclusion The clinical effect of liraglutide in the treatment of type 2 diabetes mellitus and obesity significantly.
作者 丁美
出处 《中国继续医学教育》 2016年第27期148-149,共2页 China Continuing Medical Education
关键词 利拉鲁肽 2型糖尿病 肥胖症 Liraglutide Type 2 diabetes Obesity
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  • 1胡仁明,李洪超.胰高血糖素样多肽-1类药治疗2型糖尿病的复合终点评价[J].中华糖尿病杂志,2010,2(4). 被引量:16
  • 2中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[J].中华糖尿病杂志,2012,20(1):81-117.
  • 3Kirtaniya BC,Sachdev V,Singla A,et al.Marsupialization: a conservative approach for treating dentigerous cyst in children in the mixed dentition[J]J Indian Soc Pedod Prev Dent,2010,28(3):203-208.
  • 4Lind M.Glucagon-like peptide-1(GLP-1)analogue combined with isulin reduces HbA了c and weight with low risk of hypoglycemia and high treatment satisfaction[J].Primary Care Diabetes,2012,6(1):41-47.
  • 5Li CJ,Li J,Zhang QM,et al.Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin doseincrease in Chinese subjects with poorly controlled type 2 diabetes and abdomi-nal obesity[J].Cardiovasc Diabetol,2012,11:142.
  • 6Hoist JJ.The physiology of glucagon-like peptidel[J].Physiol Rev,2007,87(4):1409-1439.
  • 7Drueker DJ,Nauck MA.The incretin system:glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes[J].Lancet,2006,368(9548):1696-1705.
  • 8Nauck MA,Meier JJ,Creutzfeldt W.Incretins and their analogues a8 new antidiabetic drugs[J].Drug News Perspect,2003,16(7):413-422.
  • 9Garber A,Henry R,Ratner R,et al.Liraglutide versus glimepiride monotherapy for type 2 diabetes(LEAD-3 Mono):a randomized,52-week,phaseⅢ,double-blind,paralleltreatment trial[J].Lancet,2009,373(56):473-481.
  • 10Marre M,Shaw J,Brandle M,et al.Liraglutide,a once-daily human GLP-1 analogue,added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes(LEAD-1 SU)[J].Diabetic Med,2009,26(8):268-278.

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