转录因子Snail与肝脏疾病的研究进展

Research Progress of Snail in Liver Disease

上皮间质转化(EMT)是人体重要的一个生理过程,近年来EMT被认为与多种肝脏疾病密切相关,如肝纤维化、肝癌(HCC)等。研究发现许多转录因子作用于上皮间质转化,其中Snail在上皮间质转化中有重要作用。文章就Snail在肝脏疾病中的研究进展作一综述。

Epithelial- mesenchymal transition is an important process in human. In recent year, EMT is considered to be related to a variety of liver diseases, such as liver fibrosis, hepatic carcinoma and so on. Many transcription factors have been found involved in the epithelial - mesenchymal transition. Snail family is one of them which play an important role in the epithelial -mesenchymal transition. In this article,the research progress on the role of Snail in EMT in liver disease was reviewed.