中医药防治颈动脉粥样硬化实验研究进展

Experimental Progress of Traditional Chinese Medicine in Prevention and Treatment of Carotid Artery Atherosclerosis

对中医药防治颈动脉粥样硬化(CAS)实验研究进展进行文献整理和分析。检索查阅与CAS实验研究相关的文献,从实验动物的选择及模型建立方法、中医药干预方法、检测指标3方面进行归纳分析。家兔是选用最多用以制造CAS模型的动物,常用球囊损伤或机械损伤或气体内膜干燥术或免疫损伤法联合高脂饮食制作CAS动物实验模型,检测指标从血清学及组织学两方面检测相关炎症因子水平及其表达。

Collect and analyze the literature about TCM experimental progress which is related to the prevention and treatment of carotid artery atherosclerosis. Review the literature about experimental progress in the prevention and treatment of CAS with TCM. This paper summarized and analyzed the literature in the following three aspects ： the selection of experimental animals and the animal modeling method;the interventions of TCM and outcome measurements. Rabbit is the most commonly - selected animal in the modeling of CAS. Balloon injury or mechanical damage or dry gas membrane or immune damage method combined with high -fat diet is often used to establish the experimental animal.