阿奇霉素联合小剂量激素治疗肺炎支原体大叶性肺炎的效果观察

Observation on the effect of azithromycin combined with low-dose prednisone on the treatment of mycoplasma lobar pneumonia

目的观察阿奇霉素联合小剂量激素治疗肺炎支原体大叶性肺炎的临床效果。方法选取在我院就诊的肺炎支原体大叶性肺炎78例,随机将其分为观察组和对照组,各39例。观察组给予阿奇霉素联合甲泼尼龙治疗,对照组仅给予阿奇霉素治疗,对比两组的临床疗效、体征消退时间及不良反应发生情况。结果观察组总有效率为97.44%,高于对照组的79.49%(P<0.05)。观察组咳嗽持续时间、发热消失时间、肺部啰音消失时间和肺部阴影消失时间均短于对照组(P<0.05)。两组不良反应发生率差异不显著(P>0.05)。结论阿奇霉素联合小剂量激素治疗肺炎支原体大叶性肺炎的效果显著,值得临床推广。

Objective To observe clinical effect of azithromycin combined with low-dose prednisone on the treatment of mycoplasma lobar pneumonia. Methods Seventy-eight cases of patients with mycoplasma lobar pneumonia were selected and were randomly divided into observation group and control group, with 39 cases in each group. The observation group received azithromycin combined with methylprednisolone, and control group received only azithromycin. The clinical curative effect, physical sign fading time and adverse effects were compared between the two groups. Results The total efficiency of observation group was 97.44%, which was significantly higher than that of control group （P 〈0.05）. The disappearance time of cough, fever, pulmonary rales and pulmonary shadow of observation group were significantly shorter than that of control group （P 〈0.05）. There was no significant difference in incidence of adverse effect between the two groups （P〉0.05）. Conclusion Azithromycin combined with small-dose of prednisone has obvious effect on the treatment of mycoplasma lobar pneumonia. It is worth for clinical promotion.