布美他尼治疗急性缺血性心力衰竭的临床疗效观察

Observation of clinical effect by bumetanide in the treatment of acute ischemic heart failure

目的观察布美他尼治疗急性缺血性心力衰竭的临床疗效。方法 100例急性缺血性心力衰竭患者,随机分为试验组和对照组,各50例。对照组采取常规治疗,试验组在对照组的基础上使用布美他尼治疗。比较两组患者的治疗总有效率和心搏量(SV)、每分输出量(CO)、左室射血分数(LVEF)、血浆脑钠肽(BNP)、6 min步行试验距离。结果试验组总有效率96.00%、SV(65.25±10.91)ml、CO(6.10±1.26)L/min、LVEF(47.80±8.28)%、血浆BNP(413.1±198.3)pg/L、6 min步行试验距离(328.34±33.81)m均优于对照组的84.00%、(54.21±8.92)ml、(4.81±0.61)L/min、(41.32±7.98)%、(510.4±165.3)pg/L、(310.69±42.29)m(P<0.05)。结论使用布美他尼治疗急性缺血性心力衰竭其临床效果显著,值得在临床推广。

Objective To observe clinical effect by bumetanide in the treatment of acute ischemic heart failure. Methods A total of 100 patients with acute ischemic heart failure were randomly divided into experimental group and control group, with 50 cases in each group. The control group received conventional therapy, and the experimental group received additional bumetanide for treatment. Comparison was made on total effective rate, stroke volume（SV）, minute output（CO）, left ventricular ejection fraction（LVEF）, plasma brain natriuretic peptide（BNP） and 6 min walking distance between the two groups. Results The experimental group had all better total effective rate as 96.00%, SV as（65.25±10.91） ml, CO as（6.10±1.26） L/min, LVEF as（47.80±8.28） %, plasma BNP as（413.1±198.3） pg/L and 6 min walking distance as（328.34±33.81） m than 84.00%,（54.21±8.92） ml,（4.81±0.61） L/min,（41.32±7.98） %,（510.4±165.3） pg/L, and（310.69±42.29） m in the control group（P〈0.05）. Conclusion Implement of bumetanide provides precise effect in treating acute ischemic heart failure, and it is worth clinical promoting.