臂踝脉搏波传导速度与尿蛋白的相关关系

Association Between Brachial-ankle Pulse Wave Velocity and Urine Protein

目的探讨臂踝脉搏波传导速度（ba PWV）对尿蛋白的影响。方法随机分层抽取唐山开滦（集团）有限责任公司在职和离退休职工中年龄≥40岁、既往无缺血性脑卒中、短暂性脑缺血发作、心肌梗死者共5440例为调查对象,排除资料不完整者,最终纳入统计分析的为5012例。进行尿蛋白检测及ba PWV检查,对ba PWV采用四分位数分组,采用多因素Logistic回归分析ba PWV对尿蛋白的影响。结果与第一分位组相比,ba PWV是尿蛋白阳性的危险因素,其OR值分别为0.778（95%CI为0.463～1.309）、1.323（95%CI为0.834～2.096）和3.172（95%CI为2.122～4.741）;校正了年龄、性别、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、舒张压、收缩压、空腹血糖以及吸烟、饮酒后,结果类似,其OR值分别为0.663（95%CI为0.424～1.036）、0.977（95%CI为0.640～1.491）和1.682（95%CI为1.073～2.637）。结论 ba PWV增加与尿蛋白相关,ba PWV增加是尿蛋白阳性的危险因素。

Aim To explore the influence of brachial-ankle pulse wave velocity（ ba PWV） on the urine protein.Methods A total of 5440 participants who were aged over 40 without previous stroke,transient ischemic attack（ TIA）and myocardial infarction were randomly selected from serving and retired workers of Tangshan Kailuan Company in 2006-2007 health examination,among which 5012 participants with integrated data were recruited into the study. Urine protein and ba PWV were detected. Grouped ba PWV using quartile group. The influence of ba PWV on urine protein was analyzed by Logistic regression. Results Compared with the first quartile group,ba PWV was a risk factor for positive urine protein,OR values were 0. 778（ 95% CI was 0. 463 ～ 1. 309）,1. 323（ 95% CI was 0. 834 ～ 2. 096） and 3. 172（ 95% CI was 2. 122 ～ 4. 741）; and adjustment for age,sex,TC,TG,HDLC,LDLC,DBP,SBP,FBG,smoking,and drinking,similar results were obtained,OR values were 0. 663（ 95% CI was 0. 424 ～ 1. 036）,0. 977（ 95% CI was 0. 640～ 1. 491） and 1. 682（ 95% CI was 1. 073 ～ 2. 637）. Conclusion The increase of ba PWV was correlated with urine protein. The increase of ba PWV was a risk factor for positive urine protein.