以非手性铕化合物为探针的手性氨基醇圆偏振荧光光谱

Circularly Polarized Luminescence Spectroscopy of Chiral Amino Alcohols Probe Detected via Achiral Europium(Ⅲ)Complex

圆偏振荧光光谱(Circularly Polarized Luminescence,CPL)是一种手性化合物表征与分析的光谱手段,然而,直接CPL检测只适用于具有特征发色团的手性化合物,这极大限制了CPL的应用范围。本文报道了一种利用非手性荧光探针分子间接检测分子手性的CPL方法。以手性氨基醇的检测为例,研究发现:非手性铕化合物Eu(fod)3探针分子可与手性氨基醇相互作用,并使得Eu(fod)3产生诱导CPL(Induced circularly polarized luminescence,ICPL)信号,该ICPL信号不仅具有较高的不对称因子glum,而且其正负性与待测手性氨基醇的手性构型表现出极大的相关性。同时,研究发现ICPL光谱的glum值对不同结构的手性氨基醇表现出不同的变化趋势。以上结果表明以非手性铕化合物Eu(fod)3为探针分子的间接CPL检测方法是手性氨基醇类分子手性构型检测的有效手段。

Circularly Polarized Luminescence（CPL）is one of chiroptical spectroscopy methods to characterize chiral molecules.However,the direct detection by CPL needs chromophore,which limits the development of CPL.In this paper,an achiral europium（Ⅲ）complex was used as probe molecule to study chiral properties in CPL.It is shown that：chiral amino alcohols can interact with the achiral europium（Ⅲ）complex Eu（fod）3and produce induced CPL signals（ICPL）.The ICPL signal exhibit highglum value and the sign was relevant with the chiral structure of the amino alcohols.Meanwhile,theglum value varies with different structures of amino alcohols.The result suggests that the indirect approach by using Eu（fod）3as probe molecule to detect chiral amino alcohols is an effective method.