新疆喀什地区维吾尔族高血压患者血清维生素D水平的初步调查

A preliminary study of serum vitamin D level in Uighur patients with hypertension in Kashgar prefecture

目的：测定喀什地区维吾尔族高血压患者血清维生素D水平，为喀什地区高血压防治提供依据。方法回顾性分析2014年1月至2015年12月在喀什地区第二人民医院就诊的200例维吾尔族高血压患者的临床资料，按危险因素将200例原发性高血压患者分为低危组（1级高血压且无其他危险因素，60例）、中危组（2级高血压或1级高血压伴1～2个危险因素，64例）和高危组（3级高血压或1～2级高血压伴≥3个危险因素或任何一级高血压伴1项靶器官损害或1种临床疾患，76例），选择同期在本院体检血压正常者66例作为健康对照组。检测4组血压和血清维生素D3水平，采用Pearson相关分析法分析维生素D3与收缩压（SBP）、舒张压（DBP）的相关性。结果高血压低、中、高危组患者SBP、DBP均显著高于健康对照组〔SBP （mmHg，1 mmHg＝0.133 kPa）：142±6、161±5、173±12比112±12， DBP（mmHg）：89±7、101±4、103±11比74±8〕，维生素D3水平明显低于健康对照组（μg/L：24±6、26±5、20±4比30±7，均P＜0.05）。维生素D3与SBP、DBP呈负相关（r值分别为-0.373、-0.324，均P＜0.01）。结论喀什地区维吾尔族高血压患者血清维生素D水平降低，尤其是伴有高危因素的患者血清维生素D水平降低更明显，建议要适当补充维生素D预防高血压。

ObjectiveTo determine the serum vitamin D levels of patients with primary hypertension to provide a basis for prevention and control of the hypertension in Kashgar prefecture.Methods The clinical data of 200 patients with hypertension in Kashgar prefecture admitted to the Second People＇s Hospital from January 2014 to December 2015 were retrospectively analyzed. According to risk factors, the 200 patients with primary hypertension were divided into three groups： 60 patients were selected as low risk group （hypertension 1 grade and no risk factors）, 64 patients were arranged into an intermediate risk group （hypertension 2 grade or hypertension 1 grade accompanied by 1-2 risk factors） and 76 patients were assigned in a high risk group （hypertension 3 grade or hypertension 1-2 grade accompanied by ≥3 risk factors or hypertension of any grade accompanied by 1 target organ damage or 1 kind of clinical disease）. In the same period, 66 healthy subjects having taken physical systemic medical examination with normal blood pressure in this hospital were grouped into a healthy control group. The levels of blood pressure and vitamin D in serum were measured, and the correlations between vitamin D and systolic blood pressure （SBP）, diastolic blood pressure （DBP） were analyzed by pearson correlation analysis in the four groups.Results The SBP and DBP were significantly higher in low, intermediate and high risk group than those in healthy control group [SBP （mmHg, 1 mmHg = 0.133 kPa）： 142±6, 161±5, 173±12 vs. 112±12, DBP （mmHg）： 89±7, 101±4, 103±11 vs. 74±8], and their levels of vitamin D were lower in low, intermediate, high risk group than the level in healthy control group （μg/L： 24±6, 26±5, 20±4 vs. 30±7, allP 〈 0.05）. Correlation analysis showed that the level of vitamin D was negatively correlated with SBP, DBP （r value was -0.373, -0.324, allP 〈 0.01）.Conclusions The serum level of vitamin D is decreased in Uighur patients with blood hypertension in Kashgar prefecture, especially in the patients with high risk factors, the descent of the serum level is more significant. It is suggested to appropriately use vitamin D supplement to prevent blood hypertension.