人肠道病毒71型疫苗研究进展

Research progress of human enterovirus 71 vaccine

人肠道病毒71型（HEV71）是引起重症手足口病的主要病原之一，感染患儿严重者可并发无菌性脑膜炎、脑干脑炎、脑脊髓炎等神经系统病变，甚至可导致死亡。近几十年来，全球多个国家和地区发生了多次大规模的手足口病暴发流行，已成为严重危害儿童健康的公共卫生问题。目前针对HEV71感染尚无特效抗病毒药物，因此研制安全有效的疫苗势在必行。近几年有关HEV71疫苗的研究取得了一定的突破，现将对该疫苗的相关研究进展作一综述。

Human enterovirus 71 （HEV71） is a major causative agent of hand,foot and mouth disease. Children infection with HEV71 can lead to series of neurological complications including aseptic meningitis ,cerebral ataxia and even fatal outcomes. During recent decades, epidemic of hand, foot and mouth disease have occurred in many coun- tries and regions in the world,which has become a major public health problem for children＇s health. There are no spe- cific antiviral drugs for HEV71 infection,so it is necessary to develop safe and effective vaccine. In recent years,the research on HEV71 vaccine has made a breakthrough, and this article reviews the research progress of the vaccine.