帕金森病患者营养状况及其相关因素分析

Analysis of nutritional status and related factors in patients with Parkinson's disease

目的研究帕金森病（PD）患者营养状况及其相关因素。方法收集180名PD患者为研究对象,应用量表系统性评估患者运动及非运动症状,采用微营养评定法（MNA-SF）评估营养状况。结果正常营养状态与非正常营养状态PD患者间病程、统一PD评分量表Ⅲ（UPDRSⅢ）、H-Y分期及非运动症状的差异均有统计学意义（P〈0.05~0.01）。二元Logistics回归结果显示H-Y分期（OR=2.35,95%CI：1.24~4.45,P=0.007）、抑郁情绪（OR=1.39,95%CI：1.25~1.67,P〈0.001）与非正常营养状态显著相关。结论 PD患者营养状况与其疾病本身、运动症状、非运动症状密切相关。

Objective To explore the nutritional status and it＇s relative factors of patients with Parkinson＇s disease（ PD）. Methods One hundred and eighty PD patients were sellected in this study. All the motor and nonmotor symptoms of PD patients were evaluated by PD scales, and mini Nutritional Assessment（ MNA）-SF questionnaires were used to evaluate their nutritional status. Results The differences of PD duration,Unified PD Rating Scale Ⅲ（ UPDRS Ⅲ）,H-Y stage and non-motor systems between normal nutritional status and abnormal nutritional status PD patients were statistically significant（ P〈0. 05- 0. 01）. The forward binary Logistic regression model indicated that H-Y stage（ OR = 2. 35,95% CI： 1. 24- 4. 45,P = 0. 007） and depression（ OR = 1. 39,95% CI：1. 25- 1. 67,P〈0. 001） were closely associated with abnormal nutritional status. Conclusion The disease itself,motor systems and non-motor systems are closely associated with nutritional status in PD patients.