双歧杆菌三联活菌散辅助经鼻空肠营养对重症急性胰腺炎患者实验室指标、并发症及经济性的影响

Influence of live combined bifidobacterium, lactobacillus and enterococcus powder assisted with nasal jejunum nutrition on laboratory index, complications and economical efficiency in patients with severe acute pancreatitis

目的：探讨双歧杆菌三联活菌散辅助经鼻空肠营养对重症急性胰腺炎（SAP）患者实验室指标、并发症发生率及经济性的影响。方法将50例SAP患者按随机抽签法分为对照组和试验组，每组25例，两组均给予SAP常规治疗，并采用经鼻空肠营养治疗；试验组在此基础上加用双歧杆菌三联活菌散辅助治疗。比较两组患者治疗前后实验室指标、胃肠功能评分、并发症、住院时间及住院费用等。结果试验组治疗后白细胞、淀粉酶、脂肪酶、C反应蛋白（CRP）、白细胞介素（IL）-8、肿瘤坏死因子（TNF）-α、乳酸脱氢酶（LDH）和胃肠功能评分均明显低于对照组[（5.9±2.1）×10^9/L比（8.4±3.1）×10^9/L、（210.4±47.6）U/L比（271.9±82.2）U/L、（205.2±22.3）U/L比（249.3±34.7）U/L、（14.7±0.4）mg/L 比（35.1±0.8）mg/L、（16.0±4.8）μg/L 比（36.5±12.9）μg/L、（21.7±5.6） ng/L 比（43.4±9.5） ng/L、（212.5±95.4） U/L 比（284.0±124.6） U/L 和（0.81±0.24）分比（1.37±0.36）分]，总并发症发生率、住院时间和住院费用明显低于对照组[12.0%（3/25）比64.0%（16/25）、（18.72±1.90） d 比（21.13±2.35） d 和（4.48±0.55）万元比（4.73±0.78）万元]，差异有统计学意义（P〈0.05）。结论双歧杆菌三联活菌散辅助经鼻空肠营养对SAP患者可有效改善实验室指标，促进胃肠功能恢复，降低并发症风险，并有助于减轻经济负担。

Objective To investigate the influence of live combined bifidobacterium, lactobacillus and enterococcus powder assisted with nasal jejunum nutrition on laboratory index, complication rate and economical efficiency in patients with severe acute pancreatitis （SAP）. Methods Fifty patients with SAP were divided into treatment group and control group by random draw method with 25 cases each. The patients of 2 groups received conventional therapy of SAP and nasal jejunum nutrition, and the patients in treatment group were treated with the above treatment combined with live combined bifidobacterium, lactobacillus and enterococcus powder. The laboratory indexes, gastrointestinal function score, complications, hospitalization time and hospitalization expenses were compared between 2 groups. Results The white blood cell, amylase, lipase, C reactive protein, interleukin （IL）-8, tumor necrosis factor （TNF）-α, lactate dehydrogenase （LDH） and gastrointestinal function score after treatment in treatment group were significantly lower than those in control group：（5.9 ± 2.1） × 10^9/L vs. （8.4 ± 3.1） × 10^9/L, （210.4 ± 47.6） U/L vs. （271.9 ± 82.2） U/L, （205.2 ± 22.3） U/L vs. （249.3 ± 34.7） U/L, （14.7 ± 0.4） mg/L vs. （35.1 ± 0.8） mg/L, （16.0 ± 4.8）μg/L vs. （36.5 ± 12.9）μg/L, （21.7 ± 5.6） ng/L vs. （43.4 ± 9.5） ng/L, （212.5 ± 95.4） U/L vs. （284.0 ± 124.6） U/L and （0.81 ± 0.24） scores vs. （1.37 ± 0.36） scores, and the total incidence of complications, hospitalization time and hospitalization expenses were significantly lower than that in control group： 12.0%（3/25） vs. 64.0%（16/25）, （18.72 ± 1.90） d vs. （21.13 ± 2.35） d and （4.48 ± 0.55） × 10^4 yuan vs. （4.73 ± 0.78） × 10^4 yuan. There were statistical differences （P〈0.05）. Conclusions Live combined bifidobacterium, lactobacillus and enterococcus powder assisted with nasal jejunum nutrition in the treatment of SAP patients can efficiently improve the laboratory indexes, promote gastrointestinal function recovery, decrease the risk of complications and reduce the economic burden.