肝动脉药泵化疗前注射利多卡因镇痛效果研究

Effect of analgesia of Lidocaine before hepatic artery pump chemotherapy

目的将利多卡因应用于肝动脉药泵化疗镇痛效果观察,了解其疗效及其临床实用性。方法将肝动脉化疗66例随机分为实验组与对照组两组。两组均泵内注射多柔比星l0mg、脱氧脱氧氟脲苷250mg,实验组在肝动脉化疗前泵内注射2%利多卡因2ml。观察两组患者腹部疼痛缓解情况及生活质量情况。结果观察组疼痛缓解率及缓解程度均较对照组好转,两组具有显著差异(P<0.05)。整体生活质量有明显的改善(P<0.05)。结论利多卡因用于肝动脉药泵化疗具有良好的镇痛效果,可在临床推广应用。

Objective To observe the analgesia efficacy and clinical practicability of lidocaine being used in chemotherapy pump of hepatic artery. Methods Sixty-six patients were randomly assigned to the experimental group and the control group. Doxorubicine（ 10mg） and doxifluridine（ 250mg） were injected through chemotherapy pump in both groups. In the experimental group 2% lidocaine（ 3ml） was injected before chemotherapy through the artery pump. Pain palliation and quality of life were investigated. Results Compared with the contol group,response rate and degree of pain and quality of life were improved significantly（ P 〈 0. 05）. Conclusion It had good analgesic effects that lidocaine was used in hepatic artery pump before chemotherapy and the method was worthy of clinical application.