孟鲁司特钠片与糖皮质激素联合应用治疗老年支气管哮喘的临床疗效

目的观察孟鲁司特钠片与糖皮质激素联合应用治疗老年支气管哮喘的疗效。方法选择110例老年支气管哮喘患者,随机分为研究组和对照组,每组55例。对照组采用布地奈德雾化吸入治疗,研究组采用孟鲁司特钠联合布地奈德治疗,比较2组临床疗效、临床症状和体征缓解时间以及白天和夜间哮喘发作次数。结果与对照组比较,研究组治疗总有效率显著增高(96.36%vs 81.82%,P<0.05);研究组症状、体征缓解时间以及白天和夜间哮喘发作次数均明显低于对照组[(5.04±1.28)d vs(5.86±1.32)d]、[(3.52±1.05)d vs(4.33±1.15)d]、[(4.38±1.08)d vs(5.23±1.17)d]、[(1.36±0.38)次vs(3.11±0.68)次]、[(0.53±0.14)次vs(1.27±0.49)次](P<0.05)。结论联合采用孟鲁司特钠片与糖皮质激素治疗老年支气管哮喘取得疗效,值得推广。

Objective To observe the clinical effect of combined application of montelukast and glucocorticoid in treatment of elderly patients with bronchial asthma. Methods 110 elderly patients with bronchial asthma were randomLy divided into study group and control group, 55 cases in each group. The control group used budesonide, and the study group used montelukast and budesonide. The clinical curative effect, the remission time of clinical symptoms and signs and frequency of asthma attacks during the day and night of the two groups were compared. Results Compared with the control group, the total effective rate of the study group was significantly higher （P〈0.05）. The remission time of clinical symptoms ad signs and rrequency of asthma attacks during the day and night of the study group was significantly lower than that of the control group （P〈0.05）. Conclusion The clinical effect of the combined use of the treatment of elderly patients with bronchial asthma with the treatment of the sodium and sodium tablets and glucocorticoid.