胰腺β细胞Bertram-Sherman模型中不同类型的簇放电模式

Different Types of Bursting Patterns in Bertram-Sherman Model of Pancreatic β Cells

簇放电是胰岛素分泌放电活动的主要模式.本文主要针对具有快慢时间尺度的胰腺β细胞Bertram-Sherman模型,研究模型中参数变化时β细胞放电活动的变化类型,并通过快慢动力学分析方法对所产生的放电模式的产生机制和动力学行为进行解释.

Bursting is the main mode of discharge activity in insulin secretion. In this paper, aiming at the Bertram-Sherman model with different time scales, the change types of β cell discharge activity when the parame- ters in the model are changed are studied. The generation mechanisms and dynamical behavior of different bursting patterns are explained using fast/slow dynamic analysis method.