99mTc-3PRGD2 SPECT/CT功能显像技术在不同部位肿瘤中的应用价值

Application of 99mTc-3PRGD2 SPECT/CT imaging in the evaluation of tumor radiotherapy at different locations

目的研究99m Tc-3PRGD2 SPECT/CT显像在不同部位肿瘤放疗疗效评价中的应用。方法选取进行放射治疗的50例肿瘤患者,其中头颈部肿瘤20例、胸部13例、腹盆部17例,分别比较99m Tc-3PRGD2SPECT/CT显像在不同部位肿瘤疗效评价的应用。根据分析结果判断疾病疗效:完全缓解、部分缓解和进展或稳定,并进一步比较不同疾病疗效下,头颈部、胸部、腹盆部在0 Gy、20 Gy、40 Gy以及60 Gy不同放疗剂量下肿瘤摄取T/N比值。结果头颈部肿瘤者阳性率明显高于腹盆部肿瘤者,差异有统计学意义(χ2=19.73,P<0.05),胸部肿瘤者阳性率明显高于头颈部肿瘤者,差异有统计学意义(χ2=9.28,P<0.05)。在0 Gy、20 Gy、40 Gy以及60 Gy不同放疗剂量下,临床疗效为部分缓解的头颈部、胸部、腹盆部肿瘤患者的T/N比值明显高于完全缓解的患者,差异均有统计学意义(t分别=4.56、5.21、5.33,P均<0.05),临床疗效为进展或稳定的头颈部、胸部、腹盆部肿瘤患者明显高于部分缓解的患者,差异均有统计学意义(t分别=4.21、4.65、5.07,P均<0.05)。结论 99m Tc-3PRGD2 SPECT/CT显像在不同部位肿瘤的阳性率不同,其中胸部肿瘤的阳性率最高,且随着放疗剂量的不断增加,患者T/N比值的差异也越来越明显,因此,99m Tc-3PRGD2 SPECT/CT是一种有效的放疗疗效评价手段。

Objective To analyze the application of 99mTc-3PRGD2 SPECT/CT imaging in the evaluation of tumor radiotherapy at different locations. Methods Fifty cases of tumor patients were selected,including 20 cases of head and neck tumors,13 cases of chest tumors and 17 cases of abdominal and pelvic tumors,the application of 99mTc-3PRGD2 SPECT/CT imaging in the evaluation of tumor response at different locations were compared. According to the results of the analysis to determine the effect of the disease： complete remission,partial remission and progression or stability,and the different curative effect of disease,head and neck,chest,abdomen and pelvis in 0 Gy,20 Gy,40 Gy and 60 Gy irradiation at different doses of tumor uptake of T/N ratio were compared. Results The positive rate of head and neck tumors was significantly higher than that of the abdominal and pelvic tumors,the difference was statistically significant（χ2=19.73,P0.05）,the positive rate of chest tumors was significantly higher than that of head and neck tumors,and the difference was statistically significant（χ2=9.28,P0.05）. In 0 Gy,20 Gy,40 Gy and 60 Gy irradiation at different doses,the T/N ratio of clinical partial remisson of head and neck,chest,abdomen and pelvic tumors were significantly higher than that of patients with complete remission,the differences were statistically significant（t=4.56,5.21,5.33,P0.05）,and clinical progression or stability of the head and neck,chest,abdominal and pelvic tumors were significantly higher than that of patients with partial remission,the differences were statistically significant（t=4.21,4.65,5.07,P 0.05）. Conclusion The positive rate of 99mTc-3PRGD2 SPECT/CT imaging at different locations is different,which the positive rate of chest tumor is the highest,and with the increasing of radiation dose,patients with T/N ratio difference is becoming more and more obvious,so 99mTc-3PRGD2 SPECT/CT is a kind of effective evaluation of radiotherapy.