骨科内植物多功能涂层研究进展

The research development of multifunctional coatings of orthopaedic implants

无菌性松动和植入物周围感染是骨科内固定术失败的两个主要原因,随着手术数量的日益增长,如何降低此类手术失败风险变得格外重要。在这个领域中,近期大量的研究工作致力于研制各种各样的内植物涂层,而这些涂层大多只具有抗感染作用而无骨整合作用;或者只具有骨整合作用而不具备抗感染作用。但是要使内植物长期有效,理想的涂层应兼顾骨整合和抗感染这两个功能。本文将对同时具有骨整合性和抗感染性的多功能涂层近期的研究进展和未来研究方向进行综述。

Aseptic loosening and periprosthetic joint infection are two main reasons responsible for internal fixation failure. With the growing number of surgeries, how to reduce the risk of surgery failure has become particularly important. A lot of research in this field were dedicated to the implant coating without combination of anti-inflammatory and osseointegration, which decides the period of validity of implants. In this review, we focus on recent progress and future possible research directions for the multifunctional coating which reaches both the anti-infection and better osseointegration properties.