原发性膀胱印戒细胞癌l例报道

A Case Report of Primary Signet-ring Cell Carcinoma of Urinary Bladder

目的探讨原发性膀胱印戒细胞癌(SRCC)的临床特点及诊疗方法。方法回顾分析1例原发性膀胱SRCC患者的临床特征、病理资料及治疗方法等资料,并结合文献进行分析和总结。结果患者术前经活检明确诊断为膀胱印戒细胞癌,在全身麻醉下行"膀胱部分切除术+膀胱脐尿管切除术",术后2 w行双侧髂内动脉灌注介入性化疗,随访1年,患者恢复良好,无复发转移。结论原发性膀胱SRCC非常罕见,进展快、恶性程度高,有早期扩散转移倾向,且临床预后差;临床表现和影像学特点无明显特征,确诊主要依靠病理组织学检查;应早期行根治性膀胱切除术,结合全身化疗等治疗,但膀胱部分切除术、膀胱脐尿管切除术加双侧髂内动脉灌注介入性化疗亦能取得更良好的疗效。

Objective To investigate the clinical features and treatment methods of primary Signet-ring Cell Carcinoma （ SRCC） of urinary bladder. Methods The clinical features, pathological data and treatment of the case with primary SRCC of bladder were re-viewed , and analyzed and summarized combined with the literature. Results The patient was explicitly diagnosed with bladder SRCC after taking the preoperative biopsy. The patient took the partial cystectomy and bladder excision of urachal with general anesthesia. Af-ter the operation, the patient took the IIW bilateral internal iliac arterial infusion interventional chemotherapy. The patient recovered well with no recurrence and metastasis at the one - year follow - up evaluation. Conclusion primary SRCC of the urinary bladder is quite rare, which shows rapid progression, high degree of malignancy, early metastasis tendency and poor clinical prognosis. Clinical manifestation and imaging feature are without obvious characteristics . Definite diagnosis mainly depends on pathological examination. The patient should take early radical cystectomy combined with systemic chemotherapy treatment. But the partial cystectomy and blad-der excision of urachal together with bilateral internal iliac artery interventional chemotherapy is helpful to get a better curative effect as well.