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microRNA与肝癌 被引量:5

microRNA and hepatocellular carcinoma
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摘要 肝癌是世界上最常见的恶性肿瘤之一,其发病率和病死率极高。microRNA(miRNA)是一类单链的非编码RNA,通常在转录后水平调控基因的表达。最近多项研究表明miRNA在肝癌中发挥着重要作用,已经成为肝癌诊断、治疗中的一个靶标。 Hepatocellular carcinoma( HCC) is one of the most common cancers worldwide and the third cause of cancer-related death. microRNA( miRNA),a class of noncoding single-stranded RNAs,posttranscriptional regulate gene expression by base pairing with the 3'untranslated regions( 3UTRs) of target messenger RNAs( mRNAs).Recent studies show that miRNA plays an important role in HCC,it has become a target diagnostic biomarkers and therapy of HCC.
出处 《基础医学与临床》 CSCD 2016年第10期1429-1432,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(31572270 31440079) 河南省自然科学基金(142300413227)
关键词 肝癌 MIRNA 诊断 治疗 hepatocellular carcinoma miRNA diagnosis therapy
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  • 1Bian-Hong Fu, Ze-Zhi Wu and Cheng Dong Chongqing, China College of Bioengineering, Key Lab for Biomechanics and Tissue Engineering under the State Ministry of Education and College of Resources & Environmental Science , Chongqing University, Chongqing 400044, China,Bioengineering Pro- gram, Pennsylvania State University, 205 Hallowell Building, University Park, Pennsylvania 16802-6804, USA.Integrin betal mediates hepatocellular carcinoma cells chemotaxis to laminin[J].Hepatobiliary & Pancreatic Diseases International,2004,3(4):548-551. 被引量:4
  • 2Bao-Hua Zhang,Han Chen,Xiao-Ping Yao,Wen-Ming Cong,Meng-Chao Wu From the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University of PLA, Shanghai 200438, China.E-selectin and its ligand-sLeX in the metastasis of hepatocellular carcinoma[J].Hepatobiliary & Pancreatic Diseases International,2002,1(1):80-82. 被引量:6
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