摘要
肝癌是世界上最常见的恶性肿瘤之一,其发病率和病死率极高。microRNA(miRNA)是一类单链的非编码RNA,通常在转录后水平调控基因的表达。最近多项研究表明miRNA在肝癌中发挥着重要作用,已经成为肝癌诊断、治疗中的一个靶标。
Hepatocellular carcinoma( HCC) is one of the most common cancers worldwide and the third cause of cancer-related death. microRNA( miRNA),a class of noncoding single-stranded RNAs,posttranscriptional regulate gene expression by base pairing with the 3'untranslated regions( 3UTRs) of target messenger RNAs( mRNAs).Recent studies show that miRNA plays an important role in HCC,it has become a target diagnostic biomarkers and therapy of HCC.
出处
《基础医学与临床》
CSCD
2016年第10期1429-1432,共4页
Basic and Clinical Medicine
基金
国家自然科学基金(31572270
31440079)
河南省自然科学基金(142300413227)
关键词
肝癌
MIRNA
诊断
治疗
hepatocellular carcinoma
miRNA
diagnosis
therapy