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长链非编码RNA在自身免疫性疾病中的研究进展 被引量：3

Research progress of long noncoding RNAs in autoimmune diseases
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摘要 长链非编码RNA(LncRNAs)是转录本长度大于等于200 nt的,不具备编码蛋白功能的RNA。LncRNAs具有基因转录、蛋白质转运及染色质重塑等功能。LncRNAs参与多种免疫性疾病的发生、发展与转归,在自身免疫性疾病中发挥重要的作用。 Long noncoding RNAs（ LncRNAs） are RNA transcripts larger than 200 nucleotides,which do not encode proteins. LncRNAs have diverse important properties,such as gene transcription,protein transport and chromatin remodeling,which involve in pathogenesis,development and prognosis of various immune diseases. The LncRNAs play crucial role in autoimmune diseases.
作者 邹利 王云甫
机构地区 湖北医药学院附属太和医院神经内科
出处 《基础医学与临床》 CSCD 2016年第10期1441-1445,共5页 Basic and Clinical Medicine
基金 湖北省科技厅自然科学基金(2010CDB09103) 湖北省教育厅重点项目(D20112102) 2014年湖北医药学院优秀中青年科技创新团队资助计划项目(2014CXX01)
关键词 长链非编码RNA 自身免疫性疾病 系统性红斑狼疮 银屑病 多发性硬化 long noncoding RNAs autoimmune diseases systemic lupus erythematosus systemic sclerosis multiple sclerosis
分类号 R593.2 [医药卫生—内科学]
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参考文献25

  • 1Djebali S, Davis CA, Merkel A, et al. Landscape of tran- scription in human cells [J]. Nature, 2012, 489: 101-108.
  • 2Wright MW, Bruford EA. Naming 'junk' : human non- protein coding RNA ( ncRNA ) gene nomenclature [ J ]. Hum Genomics, 2011, 5: 90-98.
  • 3Sun L, Goff LA, Trapnell C, et al. Long noncoding RNAs regulate adipogenesis [ J ]. Proc Natl Acad Sci U S A, 2013, 110: 3387-3392.
  • 4Singh RP, Massachi I, Manickavel S, et al. The role of miRNA in inflammation and autoimmunity [ J ]. Autoimmun Rev, 2013, 12: 1160-1165.
  • 5Jimenez SA, Piera-Velazquez S. Potential role of human- specific genes, human-specific microRNAs and human-spe- cific non-coding regulatory RNAs in the pathogenesis of sys- temic sclerosis and Sjogren's syndrome [ J ]. Autoimmun Rev, 2013, 12: 1046-1051.
  • 6Wang P, Xue Y, Han Y, et al. The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differ- entiation[J]. Science, 2014, 344: 310-313.
  • 7Wapinski O, Chang HY. Long noncoding RNAs and human disease[J]. Trends Cell Biol, 2011, 21 : 354-361.
  • 8Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs [ J ]. Cell, 2009, 136 : 629-641.
  • 9Ledford H. Circular RNAs throw genetics for a loop [ J]. Nature, 2013, 494: 415.
  • 10Fang XY, Pan HF, Leng RX, et al. Long noncoding RNAs: novel insights into gastric cancer [ J]. Cancer Lett, 2015, 356: 357-366.

二级参考文献25

  • 1Yin Z, Guan D, Fan Q, et al. LncRNA expression signatures in response to enterovirus 71 infection [ J ]. Biochem Biophys Res Commun,2013 ,430 :629-633.
  • 2Schaukowitch K, Kim TK. Emerging epigenetic mechanisms of long non-coding RNAs [ J ]. Neuroscience, 2014, 264:25-38.
  • 3Kurihara M, Shiraishi A, Satake H, et al. A conserved noncoding sequence can function as a spermatocyte-spccifie enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long non-coding RNA [ J]. J Mol Biol,2014,426:3069-3093.
  • 4Geisler C, Lojek L, Khalil AM,et al. Deeapping of long noncoding RNAs regulates inducible genes [ J ]. Mol Cell, 2012,45:279-291.
  • 5Sun M, Kraus WL. From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease [J]. Endocr Rev, 2015, 36:25-64.
  • 6Roberts TC, Morris KV, Weinberg MS. Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs[ J]. Epigenetics ,2014,9 : 13-20.
  • 7Sui WG, Lin H, Peng WJ,et al. Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long non-coding RNA [ J]. Genomics ,2013,102 : 310- 322.
  • 8Tay Y, Kats L, Salmena L,et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs [ J]. Cell,2011,147:344-357.
  • 9Leucci E, Patella F, Waage J, et al. microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus[J]. Sci Rep,2013,3 :e2535.
  • 10Tay Y, Rinn J, Pandolfi PP. The muhilayered complexity of ceRNA crosstalk and competition [J]. Nature, 2014, 505:344-352.

共引文献26

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引证文献3

二级引证文献3

基础医学与临床
2016年 第10期

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