双调蛋白的结构、表达及生理功能研究进展

Advances on the structure,expression and physiological function of amphiregulin

双调蛋白(amphiregulin)是表皮生长因子受体的配体。它的合成受多种内源性刺激和外源性刺激的影响。双调蛋白在多种组织器官中表达,参与了一系列生理过程,包括乳腺发育、胚胎着床、骨质形成、轴突生长、角化细胞增殖、女性生殖系统发育、肺、肾和前列腺的分支形态发生、精子发生、神经元和骨组织的发育和免疫功能的维持等。

Amphiregulin is the ligand of epidermal growth factor receptor. The synthesis of amphiregulin is regulated by endogenous and exogenous stimuli. Amphiregulin is expressed in a variety of tissues and takes part in series of physiological process,including mammary gland development,embryo implantation,bone formation,axon growth,keratinocyte proliferation, female reproductive system development, the branching and tubulogenesis processes of lung,kidney,and prostate,spermatogenesis,development of neuronal and bone tissues,the maintenance of immune function.