特发全面性癫基底节丘脑皮质环路的多模态MRI研究进展

Study progress of multimodal MRI in basalganglia-thalamocortical circuit of idiopathic generalized epilepsy

特发性全面性癫是一组非局灶性发病且没有明确病因的癫综合征。其发病原因至今不明,之前有研究推测丘脑皮质环路起着重要作用,目前通过MRI新技术的研究,发现了基底节-丘脑-皮质环路可能影响癫发作的产生和传播。常规MRI未能发现异常改变,而扩散张量成像、基于体素的形态测量学分析及静息态功能MRI的多模态MR新技术可从结构、体积及功能三方面发现该环路的异常改变,就其最新研究进展予以综述。

Idiopathic generalized epilepsy is a group of epileptic disorders without structural brain abnormalities and clear pathogeny of epilepsy syndrome. The etiology is still unknown. Previous studies have speculated that thalamocortical circuit plays an important role. Currently through the research of new MR technologies, the basalganglia-thalamocortical circuit is considered to be responsible for the generation and propagation of seizures. Conventional MRI can ＇t detect abnormalities, but multimodal new MRI technologies of diffusion tensor imaging, voxel based morphometry and resting-state functional MRI can find abnormal changes in this circuit from structure, volume and function. In this paper, we reviewed the recent progress of those MRI technologies.