局部血流动力学与颈动脉斑块相关性的影像技术研究

Imaging study on correlation between carotid atherosclerosis and focal hemodynamics

颈动脉粥样硬化是缺血性脑卒中的重要发病原因之一。局部血流动力学对颈动脉粥样硬化斑块的形成、发展、破裂起到至关重要的作用,如低切应力促进斑块形成,高切应力诱发斑块破裂等。基于DSA、CTA及MRI获得的三维影像数据的计算流体力学分析及MR相位对比法可获得血管的血流动力学各参数指标。综合斑块的形态、成分特征及斑块周围的血流动力学特征可为临床提供更有价值的信息。

Carotid atherosclerosis is believed to be one of the major causes for ischemic stroke. Focal hemodynamics is closely associated with carotid atherosclerosis, in aspects of formation, development, and rupture. For example, low wall shear stress promotes the formation of plaque and high wall shear stress induces the rupture of plaque.Both computational fluid dynamics derived from three-dimensional images obtained from DSA, CTA, and MRI, and phase contrast MR can be used to obtain hemodynamic parameters. Combining the morphology, composition of plaque, and the hemodynamic around plaque will provide more valuable information to clinic.