窄谱中波紫外线联合卡泊三醇软膏和卤米松乳膏治疗稳定期寻常型局限性白癜风的疗效观察

Clinical Observation of NB-UVB Combined with Calcipotriol Ointment and Halometasone Cream on Treatment of Localized Vulgaris Vitiligo in Stable Period

目的:探讨卡泊三醇联合窄谱中波紫外线(NB-UVB)及卤米松乳膏治疗稳定期寻常型局限性白癜风的临床疗效。方法:将入选的180例患者分为6组即NB-UVB治疗组20例、卡泊三醇乳膏治疗组26例、卡泊三醇联合卤米松治疗组36例、NB-UVB联合卡泊三醇治疗组27例、NB-UVB联合卤米松治疗组20例和NB-UVB联合卡泊三醇及卤米松治疗组51例,在门诊按制定的方案进行定期观察。结果:治疗12周后,6组治疗有效率分别为:NB-UVB组(15.0%)、卡泊三醇组(23.1%)、卡泊三醇联合卤米松组(47.2%)、NB-UVB联合卡泊三醇组(51.9%)、NB-UVB联合卤米松组(45.0%)、NB-UVB联合卡泊三醇和卤米松组(70.6%),NB-UVB联合卡泊三醇和卤米松组与NB-UVB组、卡泊三醇组、卡泊三醇联合卤米松组、NB-UVB联合卤米松组比较差异有统计学意义(P<0.05)。卡泊三醇联合卤米松组疗效显著好于NB-UVB组(P=0.016),与NB-UVB联合卡泊三醇组及NB-UVB联合卤米松组相比疗效无显著差异(P>0.05)。结论:在对NB-UVB无禁忌证的情况下NB-UVB联合卡泊三醇和卤米松治疗稳定型白癜风疗效较好,有禁忌证情况下卡泊三醇联合卤米松治疗稳定型白癜风疗效较满意。

Objective To explore the clinical effects of NB-UVB combined with calcipotriol ointment and halometasone cream on treating patients with localized vulgaris vitiligo in stable period.Methods Total 180 patients with vitiligo were ran- domly divided into 6 groups, including NB-UVB group（20 cases）, calcipotriol ointment group（26 cases）, calcipotriol oint- ment combined with halometasone cream group（ 36 cases）, NB-UVB combined with calcipotriol ointment group（ 27 cases）, NB-UVB combined with halometasone cream group（20 cases） and NB-UVB combined with calcipotriol ointment and halo- metasone cream group（ 51 cases）.According to the plan, these cases were regularly observed in clinic. Results After treating for 12 weeks, the curative rates was 15% in NB- UVB group, 23.1% in calcipotriol ointment group, 47.2% in calcipotriol ointment combined with halometasone cream group,51.9% in NB-UVB combined with calcipotriol ointment group,45.0% in NB-UVB combined with halometasone cream group and 70.6% in NB-UVB combined with calcipotriol ointment and halometasone cream group,respectively.The curative effect of NB-UVB combined with calcipotriol ointment and halometa- sone cream group was superior to NB-UVB group, calcipotriol ointment group, calcipotriol ointment combined with halo- metasone cream group and NB-UVB combined with halometasone cream group（P〈0.05）.The curative effect of calcipotriol ointment combined with halometasone cream group was better than that of NB-UVB group（P = 0.016）, but had no signifi- cant differences with NB-UVB ~combined with calcipotriol ointment group and NB-UVB combined with halometasone cream group（P〉0.05） .Conclusion The clinical effect of NB-UVB combined with calcipotriol ointment and halometasone cream is excellence on treating vitiligo patients without contraindication.If there was any contraindication, calcipotfiol ointment com- bined with halometasone cream must be a more suitable selection.