摘要
目的:分析蓝光辐照度在新生儿高胆红素血症蓝光治疗疗效评估中的作用。方法:选取南京市大厂医院儿科2013年6月至2014年5月收治的高胆红素血症足月新生儿90例,将其随机分为新蓝光组、部分蓝光组及旧蓝光组,每组30例。3组分别应用不同使用时间的蓝光灯予以光照治疗,观察治疗前、后血清总胆红素水平(TSB)下降情况及其与光辐照度之间的相关性。结果:3组患儿临床特征及治疗前TSB差异无统计学意义[304.3(268.6,321.3)μmol/L vs 302.6(268.6,316.2)μmol/L vs 304.3(266.9,321.3)μmol/L,z=3.239,P=0.198],经过蓝光治疗后血清TSB水平均有下降,3组TSB水平呈递增状态[146.2(134.3,158.1)μmol/L vs 180.2(156.4,195.5)μmol/L vs 200.6(190.4,214.2)μmol/L,z=44.796,P=0.000]。3组光辐照度随蓝光灯使用时间延长而逐渐下降[(30.2±2.0)μW·cm^(-2)·nm^(-1) vs(24.3±2.8)μW·cm^(-2)·nm^(-1) vs(18.1±1.9)μW·cm^(-2)·nm^(-1),F=202.872,P<0.001)。Pearson相关分析显示,TSB下降辐度(△TSB)与光辐照度呈明显正相关关系(r=0.846,P=0.000)。结论:蓝光治疗的疗效与光辐照度有关,使用时间越长的蓝光灯光辐照度下降,治疗效果下降。
Objective :To evaluate the efficacy of blue-light phototherapy using different irradiance in neo-nates with hyperbilirubinemia. Methods: 90 neonates with hyperbilirubinemia in our hospital from June 2013 to May 2014 were enrolled and randomly divided into the new blue-light group, partly ngroup and old blue-light group, each with 30 cases. The infants from different groups received different us-age time of blue light for phototherapy. The level of total serum bilirubin (TSB) and its correlation with ir- radiance were observed before and after treatment. Results: Before phototherapy, no significant difference was found in clinical characteristics and the TBS level among groups ( P 〉 0 . 05). The TSB level was evi-dently lower in all groups after phototherapy than before ( P 〈 0. 01). The light irradiance was inversely proportional to the usage time ( P 〈 0. 01). Furthermore, the reduction degree of TSB was positively cor-related with light irradiance ( r =0. 846 ,P =0. 000). Conclusion: The efficacy of blue-light phototherapy is related to the light irradiance, and the longer usage time of blue light lead to lower irradiance and poor effect.
作者
罗承洋
uo Chengyang.(Department of Peadiatrics,Dachang Hospital, Nanjing 210000, China)
出处
《广西医科大学学报》
CAS
2016年第5期815-817,共3页
Journal of Guangxi Medical University