子痫前期患者外周血及胎盘组织中半乳糖凝集素1的表达及意义

The Expression of Galectin-1 in Peripheral Blood and Placental Tissue of Preeclampsia Patients and Its Significance

目的:探讨子痫前期患者外周血及胎盘组织中半乳糖凝集素1(galectin-1,Gal-1)的表达及意义。方法:选取我院收治的早发型重度子痫前期患者53例为观察组,同期入院体检正常的孕妇53例为对照组。采用酶联免疫法检测血清Gal-1的浓度,经免疫组织化学法检测胎盘组织Gal-1蛋白的表达。结果:观察组和对照组外周血Gal-1浓度分别为(38.59±9.02)ng/L和(27.33±8.31)ng/L,2组比较差异有统计学意义(t=6.684,P<0.001)。观察组胎盘组织Gal-1的表达高于对照组,差异有统计学意义(Z=5.632,P<0.001)。结论:Gal-1可能与早发型重度子痫前期的发病有关,或可成为有价值的预测子痫前期的生物标记物。

Objective：To investigate the expression of galectin-1 in peripheral blood and placental tissue of preeclampsia patients and its significance. Methods：A total of 53 cases of early onset severe preeclampsia and 53 cases of normal pregnant people were selected as research objects. The concentration of serum Gal-1 was detected by ELISA and the expression of Gal-1 protein in placenta tissue was detected by immunohistochemistry. Results：The concentration of serum Gal-1 of the observation group and the control group were （38.59±9.02） ng/L and （27.33±8.31） ng/L, respectively. There was significant differences between the two groups （t=6.684, P〈0.001）. The expression of Gal-1 protein in observation group was significantly higher than that in the control group （Z=5.632,P〈0.001）. Conclusions：Gal-1 may be related to the early onset severe preeclampsia. It may be a valuable biomarker for predicting preeclampsia.