二甲双胍对多囊卵巢综合征患者的影响

Effects of metformin on patients with polycystic ovary syndrome

目的:探讨二甲双胍对多囊卵巢综合征患者血糖稳态、炎症标志物及氧化应激的影响。方法:选择2014年10月至2016年3月我院妇科门诊收治的96例多囊卵巢综合征患者,随机分为对照组和观察组。两组患者均服用妈富隆,观察组患者在此基础上加用二甲双胍,比较两组患者治疗前后血糖稳态、炎症标志物(hs-CRP、降钙素原、TNF-α)及氧化应激水平(NO、TAC、MDA、SOD)的变化。结果:观察组治疗后血糖、hs-CRP、降钙素原和TNF-α的水平均明显降低(P<0.05)。对照组治疗后TNF-α水平明显降低(P<0.05),hs-CRP、降钙素原无明显变化(P>0.05)。与治疗前比较,治疗后观察组NO和MDA水平明显降低,TAC和SOD水平明显升高,差异均具有统计学意义(P<0.05);治疗后对照组NO、TAC、MDA和SOD水平均无明显变化(P>0.05)。结论:二甲双胍可明显维持多囊卵巢综合征患者的血糖稳态,改善患者的炎症状态和氧化应激状态,有利于病情的恢复。

Objective： To investigate the effects of metformin on blood glucose homeostasis, inflammatory markers and oxidative stress in patients with polycystic ovary syndrome. Methods：A total of 96 research objects with polycystic ovary syndrome were selected from hospital during October 2014 to March 2016, and randomly divided into the control group and observation group. All the two groups were tak-ing marvelon, and the observation group were combined with metformin treatment, to compared the difference of two groups before and after treatment, such as blood glucose homeostasis, markers of inflammation （hs-CRP, procalcitonin, TNF-α） and oxidative stress level （NO, TAC, MDA, SOD）. Results：After treatment, the level of blood glucose, TNF-αand hs-CRP were significantly decreased in the observation group （P〈0.05）. And the level of TNF-αwas significantly decreased in the control group, while hs-CRP and had no significant change （P〉0.05）. Compared with before treatment, the level of NO and MDA were significantly decreased in the observation group （ P〈0.05）, while TAC and SOD levels were significantly increased （P〈0.05）;the level of NO, TAC, MDA and SOD had no significant change in the control group （P〉0.05）. Conclusion：Metformin can significantly maintain the blood glucose homeostasis in patients with polycystic ovary syndrome, and im-prove the inflammatory state and oxidative stress state, which is conducive to the recovery of the disease.