西药联合针刺治疗多囊卵巢综合征不孕症临床研究

Clinical Study on the Combination of Western Medicine with Acupuncture for Treatment of Polycystic Ovary Syndrome of Infertility

目的观察西药联合针刺治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症的临床疗效。方法将120例PCOS不孕症患者随机分为西药组和电针组各60例,均口服炔雌醇环丙孕酮片,有胰岛素抵抗者加服盐酸二甲双胍片,并增加运动及饮食调控,3个周期后,西药组采用枸橼酸氯米芬加绒毛膜促性腺激素促排卵,电针组予健脾补肾、调养气血方法取穴针刺促排卵治疗。比较2组治疗前后血清促卵泡素(FSH)、促黄体生成素(LH)、空腹胰岛素(FINS)、雌二醇(E2)、睾酮(T)水平。结果 2组患者治疗后T、FINS、LH、体质指数(BMI)均较治疗前下降,差异有统计学意义(P<0.05);电针组治疗后T及BMI低于西药组,差异有统计学意义(P<0.05);电针组总有效率、妊娠数、优势卵泡数、基础体温均高于西药组,差异有统计学意义(P<0.05)。结论西药联合针刺治疗PCOS不孕症疗效确切。

Objective To observe the clinical efficacy of the combination of western medicine with acupuncture for treatment of polycystic ovary syndrome（PCOS） of infertility. Methods Totally 120 PCOS patients were randomly divided into western medicine group and acupuncture group, 60 cases in each group. All patients took Diane-35, and with whom resistant to insulin were added with Metformin. At the meantime patients increased the amount of exercise with adjustment and control of everyday diet. After three periods, the western medicine group used the method of Clomifene Citrate with Chorionic Gonadotropin to help ovulation induction. The acupuncture group used the method of acupoint selection including invigorating spleen and kidney with adjusting qi and blood to promote ovulation. The level of FSH, LH, FINS, E2 and T of the two groups were observed before and after treatment. Results After treatment, the levels of T, FINS, LH and BMI in the two groups decreased, with statistical significance（P〈0.05）. The levels of T and BMI in the acupuncture group were lower than the western medicine group after the treatment, with statistical significance（P〈0.05）. The total efficiency, gestation number, number of high-quality follicle, and basal body temperature of acupuncture group were all higher than the western medicine group, with statistical significance（P〈0.05）. Conclusion The combination of western medicine with acupuncture for treatment of PCOS of infertility has confirmed efficacy.