摘要
目的探讨儿童原发性肾病综合征并发血栓栓塞的危险因素。方法回顾分析238例原发性肾病综合征患儿的临床资料,根据有无发生血栓栓塞分为栓塞组和非栓塞组,进行单因素及logistic回归分析。结果 238例患儿中,32例并发血栓栓塞,发生率为13.44%。单因素分析显示,栓塞组和非栓塞组之间,感染、利尿剂使用、水肿程度、白细胞计数、IgG、补体C3、总蛋白、白蛋白、尿素氮、血浆纤维蛋白原、D-二聚体、抗凝血酶Ⅲ、24 h尿蛋白定量的差异有统计学意义(P<0.05);多因素分析显示,D-二聚体和24 h尿蛋白定量是儿童原发性肾病综合征并发血栓栓塞的独立危险因素。结论 D-二聚体浓度增高和24 h尿蛋白定量高是儿童原发性肾病综合征并发血栓栓塞的危险因素。
Objective To explore the risk factors of primary nephritic syndrome complicated with thrombosis in children. Methods Clinical data of 238 children with primary nephritic syndrome were retrospectively analyzed. The children were divided into thrombosis group and non-thrombosis group according to whether complicated with thromboembolism. Univariate and logistic regression analysis were performed. Results Among 238 children, there were 32 cases of primary nephritic syndrome complicated with thrombosis and the rate was 13.44%. Univariate analysis showed that infections, the use of diuretic, degree of edema, white blood cell count, IgG, C3, total protein, albumin, urea nitrogen, plasma fbrinogen, D-dimer, antithrombin Ⅲ, and 24-hour proteinuria were signifcantly different between two groups (all P 〈 0.05 ). Multivariate analysis showed that D-dimer and 24-hour proteinuria were the independent risk factors for children with primary nephrotic syndrome complicated with thrombosis. Conclusion The elvated level of D-dimer and 24-hour proteinuria were the risk factors of children with primary nephrotic syndrome complicated with thrombosis.
作者
刘先炎
党西强
LIU Xianyan DANG Xiqiang(Department of Pediatric Nephrology, Children's Medical Center of the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China)
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2016年第10期767-770,共4页
Journal of Clinical Pediatrics
关键词
肾病综合征
栓塞
危险因素
儿童
nephrotic syndrome
thrombosis
risk factor
child